Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations

Monoclonal Antibodies Reveal Dynamic Plasticity Between Lgr5- and Bmi1-Expressing Intestinal Cell Populations

Continual renewal of the intestinal epithelium is dependent on active- and slow-cycling stem cells that are confined to the crypt base. Tight regulation of these stem cell populations maintains homeostasis by balancing proliferation and differentiation to support critical intestinal functions. The h...

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Bibliographic Details
Main Authors: Nicholas R. Smith, John R. Swain, Paige S. Davies, Alexandra C. Gallagher, Michael S. Parappilly, Catherine Z. Beach, Philip R. Streeter, Ian A. Williamson, Scott T. Magness, Melissa H. Wong
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Intestinal Stem Cells
Hierarchy
Lgr5
Bmi1
Plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X18300444

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