An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria.
Innate immunity is an ancient and conserved defense system that provides an early effective response against invaders. Many immune genes of Anopheles mosquitoes have been implicated in defense against a variety of pathogens, including plasmodia. Nevertheless, only recent work identified some immune...
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doaj-fde3e0a5a6414f00850c80f2570ae6022020-11-24T20:42:55ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352018-09-01129e000678510.1371/journal.pntd.0006785An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria.Ana C BahiaMarina S KubotaJayme A Souza-NetoLeonardo B KoerichAna Beatriz BarlettaHelena R C AraújoCaroline M GonçalvesCláudia M Ríos-VelásquezPaulo F P PimentaYara M Traub-CseköInnate immunity is an ancient and conserved defense system that provides an early effective response against invaders. Many immune genes of Anopheles mosquitoes have been implicated in defense against a variety of pathogens, including plasmodia. Nevertheless, only recent work identified some immune genes of Anopheles aquasalis mosquitoes upon P. vivax infection. Among these was a GATA transcription factor gene, which is described here. This is an ortholog of GATA factor Serpent genes described in Drosophila melanogaster and Anopheles gambiae. Gene expression analyses showed an increase of GATA-Serpent mRNA in P. vivax-infected A. aquasalis and functional RNAi experiments identified this transcription factor as an important immune gene of A. aquasalis against both bacteria and P. vivax. Besides, we were able to identify an effect of GATA-Serpent knockdown on A. aquasalis hemocyte proliferation and differentiation. These findings expand our understanding of the poorly studied A. aquasalis-P. vivax interactions and uncover GATA-Serpent as a key player of the mosquito innate immune response.http://europepmc.org/articles/PMC6171954?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana C Bahia Marina S Kubota Jayme A Souza-Neto Leonardo B Koerich Ana Beatriz Barletta Helena R C Araújo Caroline M Gonçalves Cláudia M Ríos-Velásquez Paulo F P Pimenta Yara M Traub-Csekö |
spellingShingle |
Ana C Bahia Marina S Kubota Jayme A Souza-Neto Leonardo B Koerich Ana Beatriz Barletta Helena R C Araújo Caroline M Gonçalves Cláudia M Ríos-Velásquez Paulo F P Pimenta Yara M Traub-Csekö An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria. PLoS Neglected Tropical Diseases |
author_facet |
Ana C Bahia Marina S Kubota Jayme A Souza-Neto Leonardo B Koerich Ana Beatriz Barletta Helena R C Araújo Caroline M Gonçalves Cláudia M Ríos-Velásquez Paulo F P Pimenta Yara M Traub-Csekö |
author_sort |
Ana C Bahia |
title |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria. |
title_short |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria. |
title_full |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria. |
title_fullStr |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria. |
title_full_unstemmed |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria. |
title_sort |
anopheles aquasalis gata factor serpent is required for immunity against plasmodium and bacteria. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2727 1935-2735 |
publishDate |
2018-09-01 |
description |
Innate immunity is an ancient and conserved defense system that provides an early effective response against invaders. Many immune genes of Anopheles mosquitoes have been implicated in defense against a variety of pathogens, including plasmodia. Nevertheless, only recent work identified some immune genes of Anopheles aquasalis mosquitoes upon P. vivax infection. Among these was a GATA transcription factor gene, which is described here. This is an ortholog of GATA factor Serpent genes described in Drosophila melanogaster and Anopheles gambiae. Gene expression analyses showed an increase of GATA-Serpent mRNA in P. vivax-infected A. aquasalis and functional RNAi experiments identified this transcription factor as an important immune gene of A. aquasalis against both bacteria and P. vivax. Besides, we were able to identify an effect of GATA-Serpent knockdown on A. aquasalis hemocyte proliferation and differentiation. These findings expand our understanding of the poorly studied A. aquasalis-P. vivax interactions and uncover GATA-Serpent as a key player of the mosquito innate immune response. |
url |
http://europepmc.org/articles/PMC6171954?pdf=render |
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