Evaluation of analgesic and anti-inflammatory activities of ethanolic extract of Cordia sebestena L.

• Main Authors: Sunaryo H., Siska S., Hanani E., Anindita RS., Yanti N., Lisa
• Format: Article
• Language: English
• Published: Sciendo 2019-11-01
• Series: European Pharmaceutical Journal
• Subjects: analgesic; anti-inflammatory; carrageenan; cordia sebestena; hot plate; writhing
• Online Access: https://doi.org/10.2478/afpuc-2019-0018

Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats. The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract (100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and clinical settings.