Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance.

Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance.

Bacterial signaling systems are prime drug targets for combating the global health threat of antibiotic resistant bacterial infections including those caused by Staphylococcus aureus. S. aureus is the primary cause of acute bacterial skin and soft tissue infections (SSTIs) and the quorum sensing ope...

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Bibliographic Details
Main Authors: Erin K Sully, Natalia Malachowa, Bradley O Elmore, Susan M Alexander, Jon K Femling, Brian M Gray, Frank R DeLeo, Michael Otto, Ambrose L Cheung, Bruce S Edwards, Larry A Sklar, Alexander R Horswill, Pamela R Hall, Hattie D Gresham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4055767?pdf=render

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