Insights into Characterization Methods and Biomedical Applications of Nanoparticle–Protein Corona
Nanoparticles (NPs) exposed to a biological milieu will strongly interact with proteins, forming “coronas” on the surfaces of the NPs. The protein coronas (PCs) affect the properties of the NPs and provide a new biological identity to the particles in the biological environment. The characterization...
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doaj-fdf7abfebbab4f7ebd8d375e7c6341a72020-11-25T03:43:28ZengMDPI AGMaterials1996-19442020-07-01133093309310.3390/ma13143093Insights into Characterization Methods and Biomedical Applications of Nanoparticle–Protein CoronaYan Li0Jae-Seung Lee1Materials Science and Engineering, Korea University 145 Anam-ro, Seongbuk-gu, Seoul 02841, KoreaMaterials Science and Engineering, Korea University 145 Anam-ro, Seongbuk-gu, Seoul 02841, KoreaNanoparticles (NPs) exposed to a biological milieu will strongly interact with proteins, forming “coronas” on the surfaces of the NPs. The protein coronas (PCs) affect the properties of the NPs and provide a new biological identity to the particles in the biological environment. The characterization of NP-PC complexes has attracted enormous research attention, owing to the crucial effects of the properties of an NP-PC on its interactions with living systems, as well as the diverse applications of NP-PC complexes. The analysis of NP-PC complexes without a well-considered approach will inevitably lead to misunderstandings and inappropriate applications of NPs. This review introduces methods for the characterization of NP-PC complexes and investigates their recent applications in biomedicine. Furthermore, the review evaluates these characterization methods based on comprehensive critical views and provides future perspectives regarding the applications of NP-PC complexes.https://www.mdpi.com/1996-1944/13/14/3093nanoparticlesprotein coronacharacterizationbiomedical application |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan Li Jae-Seung Lee |
spellingShingle |
Yan Li Jae-Seung Lee Insights into Characterization Methods and Biomedical Applications of Nanoparticle–Protein Corona Materials nanoparticles protein corona characterization biomedical application |
author_facet |
Yan Li Jae-Seung Lee |
author_sort |
Yan Li |
title |
Insights into Characterization Methods and Biomedical Applications of Nanoparticle–Protein Corona |
title_short |
Insights into Characterization Methods and Biomedical Applications of Nanoparticle–Protein Corona |
title_full |
Insights into Characterization Methods and Biomedical Applications of Nanoparticle–Protein Corona |
title_fullStr |
Insights into Characterization Methods and Biomedical Applications of Nanoparticle–Protein Corona |
title_full_unstemmed |
Insights into Characterization Methods and Biomedical Applications of Nanoparticle–Protein Corona |
title_sort |
insights into characterization methods and biomedical applications of nanoparticle–protein corona |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2020-07-01 |
description |
Nanoparticles (NPs) exposed to a biological milieu will strongly interact with proteins, forming “coronas” on the surfaces of the NPs. The protein coronas (PCs) affect the properties of the NPs and provide a new biological identity to the particles in the biological environment. The characterization of NP-PC complexes has attracted enormous research attention, owing to the crucial effects of the properties of an NP-PC on its interactions with living systems, as well as the diverse applications of NP-PC complexes. The analysis of NP-PC complexes without a well-considered approach will inevitably lead to misunderstandings and inappropriate applications of NPs. This review introduces methods for the characterization of NP-PC complexes and investigates their recent applications in biomedicine. Furthermore, the review evaluates these characterization methods based on comprehensive critical views and provides future perspectives regarding the applications of NP-PC complexes. |
topic |
nanoparticles protein corona characterization biomedical application |
url |
https://www.mdpi.com/1996-1944/13/14/3093 |
work_keys_str_mv |
AT yanli insightsintocharacterizationmethodsandbiomedicalapplicationsofnanoparticleproteincorona AT jaeseunglee insightsintocharacterizationmethodsandbiomedicalapplicationsofnanoparticleproteincorona |
_version_ |
1724519706063273984 |