Myeloperoxidase Negatively Regulates Neutrophil–Endothelial Cell Interactions by Impairing αMβ2 Integrin Function in Sterile Inflammation

Myeloperoxidase Negatively Regulates Neutrophil–Endothelial Cell Interactions by Impairing αMβ2 Integrin Function in Sterile Inflammation

Interactions of neutrophils with endothelial cells (ECs) and platelets contribute to tissue damage and vascular occlusion under sterile inflammatory conditions. However, the molecular mechanisms regulating the cell–cell interactions remain poorly understood. Previous studies suggest that reactive ox...

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Bibliographic Details
Main Authors: Alan Tseng, Kyungho Kim, Jing Li, Jaehyung Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Medicine
Subjects:
neutrophil
myeloperoxidase
αMβ2 integrin
vascular inflammation
intravital microscopy
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2018.00134/full

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