Efficacy and Safety of Fingolimod in Daily Practice: Experience of an Academic MS French Center
IntroductionFingolimod (Fg), a sphingosine 1-phosphate receptor modulator, decreases the annual relapse rate (ARR) in relapsing-remitting multiple sclerosis (RRMS). The aim of this study was to assess the efficacy and safety of Fg in daily practice in patients with RRMS, previously treated with nata...
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doaj-fe1a7ea3998b4bfbaff1e06e58185e542020-11-24T23:53:21ZengFrontiers Media S.A.Frontiers in Neurology1664-22952017-05-01810.3389/fneur.2017.00183259828Efficacy and Safety of Fingolimod in Daily Practice: Experience of an Academic MS French CenterThomas Roux0Elisabeth Maillart1Jean-Sébastien Vidal2Sophie Tezenas du Montcel3Catherine Lubetzki4Caroline Papeix5AP-HP, Neurology Department, Pitié-Salpétrière Hospital, Paris, FranceAP-HP, Neurology Department, Pitié-Salpétrière Hospital, Paris, FranceAP-HP, Neurology, Broca Hospital, Paris, FranceAP-HP, Biostatistics Department, Pitié-Salpétrière Hospital, Paris, FranceAP-HP, Neurology Department, Pitié-Salpétrière Hospital, Paris, FranceAP-HP, Neurology Department, Pitié-Salpétrière Hospital, Paris, FranceIntroductionFingolimod (Fg), a sphingosine 1-phosphate receptor modulator, decreases the annual relapse rate (ARR) in relapsing-remitting multiple sclerosis (RRMS). The aim of this study was to assess the efficacy and safety of Fg in daily practice in patients with RRMS, previously treated with natalizumab (Nz) or not, and systematically followed during at least 1 year.MethodsData were collected from the patient files. Primary endpoint was the comparison between the ARR the year before Fg onset and after 1 and 2 years of Fg treatment. The secondary endpoints were the difference between Expanded Disability Status Scale (EDSS) at Fg onset and after 1 and 2 years of treatment, and safety.ResultsIn the whole sample, we confirmed Fg efficacy on the ARR (0.895 before vs. 0.364 1 year after, p < 0.0001). Between our two groups (with or without Nz before Fg), the ARR was higher in the Nz group during the first year but similar during the second year. The EDSS was stable during the first year of Fg but significantly higher after 2 years (3.33 vs. 3.72, p = 0.02). Concerning safety, only three patients had to discontinue Fg because of tolerance issues.ConclusionOur study showed that Fg is safe in RRMS and can be used either after first-line treatments or after Nz. However we observed a mild disability progression after 2 years.http://journal.frontiersin.org/article/10.3389/fneur.2017.00183/fullfingolimodrelapsing-remitting multiple sclerosisefficacyannual relapse ratedisabilitysafety |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Thomas Roux Elisabeth Maillart Jean-Sébastien Vidal Sophie Tezenas du Montcel Catherine Lubetzki Caroline Papeix |
spellingShingle |
Thomas Roux Elisabeth Maillart Jean-Sébastien Vidal Sophie Tezenas du Montcel Catherine Lubetzki Caroline Papeix Efficacy and Safety of Fingolimod in Daily Practice: Experience of an Academic MS French Center Frontiers in Neurology fingolimod relapsing-remitting multiple sclerosis efficacy annual relapse rate disability safety |
author_facet |
Thomas Roux Elisabeth Maillart Jean-Sébastien Vidal Sophie Tezenas du Montcel Catherine Lubetzki Caroline Papeix |
author_sort |
Thomas Roux |
title |
Efficacy and Safety of Fingolimod in Daily Practice: Experience of an Academic MS French Center |
title_short |
Efficacy and Safety of Fingolimod in Daily Practice: Experience of an Academic MS French Center |
title_full |
Efficacy and Safety of Fingolimod in Daily Practice: Experience of an Academic MS French Center |
title_fullStr |
Efficacy and Safety of Fingolimod in Daily Practice: Experience of an Academic MS French Center |
title_full_unstemmed |
Efficacy and Safety of Fingolimod in Daily Practice: Experience of an Academic MS French Center |
title_sort |
efficacy and safety of fingolimod in daily practice: experience of an academic ms french center |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2017-05-01 |
description |
IntroductionFingolimod (Fg), a sphingosine 1-phosphate receptor modulator, decreases the annual relapse rate (ARR) in relapsing-remitting multiple sclerosis (RRMS). The aim of this study was to assess the efficacy and safety of Fg in daily practice in patients with RRMS, previously treated with natalizumab (Nz) or not, and systematically followed during at least 1 year.MethodsData were collected from the patient files. Primary endpoint was the comparison between the ARR the year before Fg onset and after 1 and 2 years of Fg treatment. The secondary endpoints were the difference between Expanded Disability Status Scale (EDSS) at Fg onset and after 1 and 2 years of treatment, and safety.ResultsIn the whole sample, we confirmed Fg efficacy on the ARR (0.895 before vs. 0.364 1 year after, p < 0.0001). Between our two groups (with or without Nz before Fg), the ARR was higher in the Nz group during the first year but similar during the second year. The EDSS was stable during the first year of Fg but significantly higher after 2 years (3.33 vs. 3.72, p = 0.02). Concerning safety, only three patients had to discontinue Fg because of tolerance issues.ConclusionOur study showed that Fg is safe in RRMS and can be used either after first-line treatments or after Nz. However we observed a mild disability progression after 2 years. |
topic |
fingolimod relapsing-remitting multiple sclerosis efficacy annual relapse rate disability safety |
url |
http://journal.frontiersin.org/article/10.3389/fneur.2017.00183/full |
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