The association between serum leptin and post stroke depression: results from a cohort study.
BACKGROUND: Depression is a frequent mood disorder that affects around a third of stroke patients and has been associated with poorer outcomes. Our aim was to determine whether there was a relationship between inflammatory markers (leptin) and post-stroke depression (PSD). METHODS: One hundred and n...
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doaj-fe209efac5fe4057b3ce4ce2c2fa4c932020-11-25T01:19:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10313710.1371/journal.pone.0103137The association between serum leptin and post stroke depression: results from a cohort study.Yan-tao LiYe ZhaoHua-jing ZhangWen-li ZhaoBACKGROUND: Depression is a frequent mood disorder that affects around a third of stroke patients and has been associated with poorer outcomes. Our aim was to determine whether there was a relationship between inflammatory markers (leptin) and post-stroke depression (PSD). METHODS: One hundred and ninety-one ischemic stroke patients admitted to the hospital within the first 24 hours after stroke onset were consecutively recruited and followed up for 3 months. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of leptin at admission. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for post-stroke depression at 3 month. RESULTS: Forty-four patients (23.0%) were diagnosed as having major depression at 3 month. Patients with depression showed higher serum leptin levels at 3 month after stroke (32.2 [IQR, 20.8-57.7] v. 9.9 [IQR, 4.6-13.1]ng/ml, respectively; P = 0.000). Serum levels of leptin ≥20 ng/ml were independently associated with PSD [odds ratio (OR) 20.23, 95% confidence interval (CI) 9.11-51.26, P = 0.000], after adjusting for possible confounders. CONCLUSIONS: Serum leptin levels elevated at admission were found to be associated with PSD and may provide a new proposal for the treatment of PSD.http://europepmc.org/articles/PMC4111552?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yan-tao Li Ye Zhao Hua-jing Zhang Wen-li Zhao |
spellingShingle |
Yan-tao Li Ye Zhao Hua-jing Zhang Wen-li Zhao The association between serum leptin and post stroke depression: results from a cohort study. PLoS ONE |
author_facet |
Yan-tao Li Ye Zhao Hua-jing Zhang Wen-li Zhao |
author_sort |
Yan-tao Li |
title |
The association between serum leptin and post stroke depression: results from a cohort study. |
title_short |
The association between serum leptin and post stroke depression: results from a cohort study. |
title_full |
The association between serum leptin and post stroke depression: results from a cohort study. |
title_fullStr |
The association between serum leptin and post stroke depression: results from a cohort study. |
title_full_unstemmed |
The association between serum leptin and post stroke depression: results from a cohort study. |
title_sort |
association between serum leptin and post stroke depression: results from a cohort study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
BACKGROUND: Depression is a frequent mood disorder that affects around a third of stroke patients and has been associated with poorer outcomes. Our aim was to determine whether there was a relationship between inflammatory markers (leptin) and post-stroke depression (PSD). METHODS: One hundred and ninety-one ischemic stroke patients admitted to the hospital within the first 24 hours after stroke onset were consecutively recruited and followed up for 3 months. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of leptin at admission. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for post-stroke depression at 3 month. RESULTS: Forty-four patients (23.0%) were diagnosed as having major depression at 3 month. Patients with depression showed higher serum leptin levels at 3 month after stroke (32.2 [IQR, 20.8-57.7] v. 9.9 [IQR, 4.6-13.1]ng/ml, respectively; P = 0.000). Serum levels of leptin ≥20 ng/ml were independently associated with PSD [odds ratio (OR) 20.23, 95% confidence interval (CI) 9.11-51.26, P = 0.000], after adjusting for possible confounders. CONCLUSIONS: Serum leptin levels elevated at admission were found to be associated with PSD and may provide a new proposal for the treatment of PSD. |
url |
http://europepmc.org/articles/PMC4111552?pdf=render |
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