An Evolutionary View of Trypanosoma Cruzi Telomeres
Like in most eukaryotes, the linear chromosomes of Trypanosoma cruzi end in a nucleoprotein structure called the telomere, which is preceded by regions of variable length called subtelomeres. Together telomeres and subtelomeres are dynamic sites where DNA sequence rearrangements can occur without co...
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doaj-fe20cdd004ab4042a95d991221a2a7d22020-11-25T02:39:35ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-01-01910.3389/fcimb.2019.00439500725An Evolutionary View of Trypanosoma Cruzi TelomeresJose Luis RamirezLike in most eukaryotes, the linear chromosomes of Trypanosoma cruzi end in a nucleoprotein structure called the telomere, which is preceded by regions of variable length called subtelomeres. Together telomeres and subtelomeres are dynamic sites where DNA sequence rearrangements can occur without compromising essential interstitial genes or chromosomal synteny. Good examples of subtelomeres involvement are the expansion of human olfactory receptors genes, variant surface antigens in Trypanosoma brucei, and Saccharomyces cerevisiae mating types. T. cruzi telomeres are made of long stretches of the hexameric repeat 5′-TTAGGG-OH-3′, and its subtelomeres are enriched in genes and pseudogenes from the large gene families RHS, TS and DGF1, DEAD/H-RNA helicase and N-acetyltransferase, intermingled with sequences of retrotransposons elements. In particular, members of the Trans-sialidase type II family appear to have played a role in shaping the current T. cruzi telomere structure. Although the structure and function of T. cruzi telomeric and subtelomeric regions have been documented, recent experiments are providing new insights into T. cruzi's telomere-subtelomere dynamics. In this review, I discuss the co-evolution of telomere, subtelomeres and the TS gene family, and the role that these regions may have played in shaping T. cruzi's genome.https://www.frontiersin.org/article/10.3389/fcimb.2019.00439/fullTrypanosoma cruzi (T. cruzi)telomeresevolutioanry dyanmicsgenomesialidases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jose Luis Ramirez |
spellingShingle |
Jose Luis Ramirez An Evolutionary View of Trypanosoma Cruzi Telomeres Frontiers in Cellular and Infection Microbiology Trypanosoma cruzi (T. cruzi) telomeres evolutioanry dyanmics genome sialidases |
author_facet |
Jose Luis Ramirez |
author_sort |
Jose Luis Ramirez |
title |
An Evolutionary View of Trypanosoma Cruzi Telomeres |
title_short |
An Evolutionary View of Trypanosoma Cruzi Telomeres |
title_full |
An Evolutionary View of Trypanosoma Cruzi Telomeres |
title_fullStr |
An Evolutionary View of Trypanosoma Cruzi Telomeres |
title_full_unstemmed |
An Evolutionary View of Trypanosoma Cruzi Telomeres |
title_sort |
evolutionary view of trypanosoma cruzi telomeres |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2020-01-01 |
description |
Like in most eukaryotes, the linear chromosomes of Trypanosoma cruzi end in a nucleoprotein structure called the telomere, which is preceded by regions of variable length called subtelomeres. Together telomeres and subtelomeres are dynamic sites where DNA sequence rearrangements can occur without compromising essential interstitial genes or chromosomal synteny. Good examples of subtelomeres involvement are the expansion of human olfactory receptors genes, variant surface antigens in Trypanosoma brucei, and Saccharomyces cerevisiae mating types. T. cruzi telomeres are made of long stretches of the hexameric repeat 5′-TTAGGG-OH-3′, and its subtelomeres are enriched in genes and pseudogenes from the large gene families RHS, TS and DGF1, DEAD/H-RNA helicase and N-acetyltransferase, intermingled with sequences of retrotransposons elements. In particular, members of the Trans-sialidase type II family appear to have played a role in shaping the current T. cruzi telomere structure. Although the structure and function of T. cruzi telomeric and subtelomeric regions have been documented, recent experiments are providing new insights into T. cruzi's telomere-subtelomere dynamics. In this review, I discuss the co-evolution of telomere, subtelomeres and the TS gene family, and the role that these regions may have played in shaping T. cruzi's genome. |
topic |
Trypanosoma cruzi (T. cruzi) telomeres evolutioanry dyanmics genome sialidases |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2019.00439/full |
work_keys_str_mv |
AT joseluisramirez anevolutionaryviewoftrypanosomacruzitelomeres AT joseluisramirez evolutionaryviewoftrypanosomacruzitelomeres |
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