Human leucocyte antigen class I in hormone receptor-positive, HER2-negative breast cancer: association with response and survival after neoadjuvant chemotherapy

Human leucocyte antigen class I in hormone receptor-positive, HER2-negative breast cancer: association with response and survival after neoadjuvant chemotherapy

Abstract Background Clinical application of cancer immunotherapy requires a better understanding of tumor immunogenicity and the tumor microenvironment. HLA class I molecules present antigens to CD8+ cytotoxic cells. Their loss or downregulation is frequently found in tumors resulting in reduced T c...

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Bibliographic Details
Main Authors: Bruno Valentin Sinn, Karsten E. Weber, Wolfgang Daniel Schmitt, Peter A. Fasching, William Fraser Symmans, Jens-Uwe Blohmer, Thomas Karn, Eliane Tabea Taube, Frederick Klauschen, Frederik Marmé, Christian Schem, Elmar Stickeler, Beyhan Ataseven, Jens Huober, Gunter von Minckwitz, Barbara Seliger, Carsten Denkert, Sibylle Loibl
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Breast Cancer Research
Subjects:
Breast cancer
HLA
Tumor-infiltrating lymphocytes
Online Access:https://doi.org/10.1186/s13058-019-1231-z

Internet

https://doi.org/10.1186/s13058-019-1231-z

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