Recent Advances in Mitochondria-Targeted Gene Delivery
Mitochondria are the energy-producing organelles of cells. Mitochondrial dysfunctions link to various syndromes and diseases including myoclonic epilepsy and ragged-red fiber disease (MERRF), Leigh syndrome (LS), and Leber hereditary optic neuropathy (LHON). Primary mitochondrial diseases often resu...
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doaj-fe2e842f195943b998345bf5536a95272020-11-24T23:39:16ZengMDPI AGMolecules1420-30492018-09-01239231610.3390/molecules23092316molecules23092316Recent Advances in Mitochondria-Targeted Gene DeliveryYoon-ha Jang0Kwang-il Lim1Department of Chemical and Biological Engineering, Sookmyung Women’s University, Seoul 04310, KoreaDepartment of Chemical and Biological Engineering, Sookmyung Women’s University, Seoul 04310, KoreaMitochondria are the energy-producing organelles of cells. Mitochondrial dysfunctions link to various syndromes and diseases including myoclonic epilepsy and ragged-red fiber disease (MERRF), Leigh syndrome (LS), and Leber hereditary optic neuropathy (LHON). Primary mitochondrial diseases often result from mutations of mitochondrial genomes and nuclear genes that encode the mitochondrial components. However, complete intracellular correction of the mutated genetic parts relevant to mitochondrial structures and functions is technically challenging. Instead, there have been diverse attempts to provide corrected genetic materials with cells. In this review, we discuss recent novel physical, chemical and biological strategies, and methods to introduce genetic cargos into mitochondria of eukaryotic cells. Effective mitochondria-targeting gene delivery systems can reverse multiple mitochondrial disorders by enabling cells to produce functional mitochondrial components.http://www.mdpi.com/1420-3049/23/9/2316mitochondrial gene deliverymitochondrial diseasemitochondrial genomesheteroplasmymitochondrial matrix |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yoon-ha Jang Kwang-il Lim |
spellingShingle |
Yoon-ha Jang Kwang-il Lim Recent Advances in Mitochondria-Targeted Gene Delivery Molecules mitochondrial gene delivery mitochondrial disease mitochondrial genomes heteroplasmy mitochondrial matrix |
author_facet |
Yoon-ha Jang Kwang-il Lim |
author_sort |
Yoon-ha Jang |
title |
Recent Advances in Mitochondria-Targeted Gene Delivery |
title_short |
Recent Advances in Mitochondria-Targeted Gene Delivery |
title_full |
Recent Advances in Mitochondria-Targeted Gene Delivery |
title_fullStr |
Recent Advances in Mitochondria-Targeted Gene Delivery |
title_full_unstemmed |
Recent Advances in Mitochondria-Targeted Gene Delivery |
title_sort |
recent advances in mitochondria-targeted gene delivery |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2018-09-01 |
description |
Mitochondria are the energy-producing organelles of cells. Mitochondrial dysfunctions link to various syndromes and diseases including myoclonic epilepsy and ragged-red fiber disease (MERRF), Leigh syndrome (LS), and Leber hereditary optic neuropathy (LHON). Primary mitochondrial diseases often result from mutations of mitochondrial genomes and nuclear genes that encode the mitochondrial components. However, complete intracellular correction of the mutated genetic parts relevant to mitochondrial structures and functions is technically challenging. Instead, there have been diverse attempts to provide corrected genetic materials with cells. In this review, we discuss recent novel physical, chemical and biological strategies, and methods to introduce genetic cargos into mitochondria of eukaryotic cells. Effective mitochondria-targeting gene delivery systems can reverse multiple mitochondrial disorders by enabling cells to produce functional mitochondrial components. |
topic |
mitochondrial gene delivery mitochondrial disease mitochondrial genomes heteroplasmy mitochondrial matrix |
url |
http://www.mdpi.com/1420-3049/23/9/2316 |
work_keys_str_mv |
AT yoonhajang recentadvancesinmitochondriatargetedgenedelivery AT kwangillim recentadvancesinmitochondriatargetedgenedelivery |
_version_ |
1725514307196682240 |