Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats
Abstract The use of herbal remedies is significantly considered in the atherosclerosis treatment, reduction of fatty elements, and prevention of activity of oxidative stress factors. The present study was conducted on 48 rats in 6 groups. The experimental and sham groups were fed with 2% cholesterol...
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doaj-fe318c976fb34c4a8841421bb94bd9062020-11-24T22:01:02ZengWileyFood Science & Nutrition2048-71772019-09-01792875288710.1002/fsn3.1136Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar ratsAli Parvin0Parichehreh Yaghmaei1Mehdi Noureddini2Sayyed Ali Haeri Roohani3Saeed Aminzadeh4Department of Biology, Science and Research Branch Islamic Azad University Tehran IranDepartment of Biology, Science and Research Branch Islamic Azad University Tehran IranPhysiology Research Center Kashan University of Medical Sciences Kashan IranDepartment of Biology, Science and Research Branch Islamic Azad University Tehran IranBioprocess Engineering Research Group National Institute of Genetic Engineering and Biotechnology Tehran IranAbstract The use of herbal remedies is significantly considered in the atherosclerosis treatment, reduction of fatty elements, and prevention of activity of oxidative stress factors. The present study was conducted on 48 rats in 6 groups. The experimental and sham groups were fed with 2% cholesterol for 40 days; and experimental groups were separately treated by atorvastatin, quercetin, and hydroalcoholic extract for 4 weeks. After treatment procedure, some serum factors such as low‐density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA), and reactive oxygen species (ROS) were evaluated. Serum levels of LDL, TC, MDA, and ROS were significantly lower in experimental groups than sham group (p < .01). There was a significant decrease in serum MDA levels of these two groups in comparison with the atorvastatin‐treated group (p < .05). Blood pressure parameters were decreased in treated with quercetin and hydroalcoholic extract in comparison with the sham group (p < .05). Quercetin and hydroalcoholic extract similar to atorvastatin could decrease serum lipids [except high‐density lipoprotein (HDL)], oxidative stress factors, aorta contraction, weight gain, and blood pressure. These reagents improved the vascular structure and prevented the plaque formation.https://doi.org/10.1002/fsn3.1136atherosclerosisatorvastatinhydroalcoholic extractotostegia persica Boissquercetin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ali Parvin Parichehreh Yaghmaei Mehdi Noureddini Sayyed Ali Haeri Roohani Saeed Aminzadeh |
spellingShingle |
Ali Parvin Parichehreh Yaghmaei Mehdi Noureddini Sayyed Ali Haeri Roohani Saeed Aminzadeh Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats Food Science & Nutrition atherosclerosis atorvastatin hydroalcoholic extract otostegia persica Boiss quercetin |
author_facet |
Ali Parvin Parichehreh Yaghmaei Mehdi Noureddini Sayyed Ali Haeri Roohani Saeed Aminzadeh |
author_sort |
Ali Parvin |
title |
Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats |
title_short |
Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats |
title_full |
Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats |
title_fullStr |
Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats |
title_full_unstemmed |
Comparative effects of quercetin and hydroalcoholic extract of Otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats |
title_sort |
comparative effects of quercetin and hydroalcoholic extract of otostegia persica boiss with atorvastatin on atherosclerosis complication in male wistar rats |
publisher |
Wiley |
series |
Food Science & Nutrition |
issn |
2048-7177 |
publishDate |
2019-09-01 |
description |
Abstract The use of herbal remedies is significantly considered in the atherosclerosis treatment, reduction of fatty elements, and prevention of activity of oxidative stress factors. The present study was conducted on 48 rats in 6 groups. The experimental and sham groups were fed with 2% cholesterol for 40 days; and experimental groups were separately treated by atorvastatin, quercetin, and hydroalcoholic extract for 4 weeks. After treatment procedure, some serum factors such as low‐density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA), and reactive oxygen species (ROS) were evaluated. Serum levels of LDL, TC, MDA, and ROS were significantly lower in experimental groups than sham group (p < .01). There was a significant decrease in serum MDA levels of these two groups in comparison with the atorvastatin‐treated group (p < .05). Blood pressure parameters were decreased in treated with quercetin and hydroalcoholic extract in comparison with the sham group (p < .05). Quercetin and hydroalcoholic extract similar to atorvastatin could decrease serum lipids [except high‐density lipoprotein (HDL)], oxidative stress factors, aorta contraction, weight gain, and blood pressure. These reagents improved the vascular structure and prevented the plaque formation. |
topic |
atherosclerosis atorvastatin hydroalcoholic extract otostegia persica Boiss quercetin |
url |
https://doi.org/10.1002/fsn3.1136 |
work_keys_str_mv |
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