MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.

MAP kinase signaling has been implicated in brain development, long-term memory, and the response to antidepressants. Inducible Braf knockout mice, which exhibit protein depletion in principle forebrain neurons, enabled us to unravel a new role of neuronal MAPK signaling for emotional behavior. Braf...

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Bibliographic Details
Main Authors: Benedikt Wefers, Christiane Hitz, Sabine M Hölter, Dietrich Trümbach, Jens Hansen, Peter Weber, Benno Pütz, Jan M Deussing, Martin Hrabé de Angelis, Till Roenneberg, Fang Zheng, Christian Alzheimer, Alcino Silva, Wolfgang Wurst, Ralf Kühn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3329550?pdf=render

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