Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese Mice
Obesity-associated hyperglycemia underlies insulin resistance, glucose intolerance, and related metabolic disorders including type 2 diabetes, renal damage, and nonalcoholic fatty liver disease. Turmeric root is commonly used in Asia, and curcumin, one of its pharmacological components, can play a r...
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doaj-fe3952678454484d848f0eb79af806452021-07-23T14:03:04ZengMDPI AGProcesses2227-97172021-06-0191132113210.3390/pr9071132Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese MiceGeng-Ruei Chang0Wen-Tsong Hsieh1Lan-Szu Chou2Chen-Si Lin3Ching-Fen Wu4Jen-Wei Lin5Wei-Li Lin6Tzu-Chun Lin7Huei-Jyuan Liao8Chen-Yung Kao9Chuen-Fu Lin10Department of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, TaiwanDepartment of Pharmacology, China Medical University, 91 Hsueh-Shih Road, Taichung 404333, TaiwanDepartment of BioAgricultural Sciences, National Chiayi University, 300 Syuefu Road, Chiayi 60004, TaiwanSchool of Veterinary Medicine, National Taiwan University, 4 Section, 1 Roosevelt Road, Taipei 10617, TaiwanDepartment of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, TaiwanBachelor Degree Program in Animal Healthcare, Hungkuang University, 6 Section, 1018 Taiwan Boulevard, Shalu District, Taichung 433304, TaiwanBachelor Degree Program in Animal Healthcare, Hungkuang University, 6 Section, 1018 Taiwan Boulevard, Shalu District, Taichung 433304, TaiwanDepartment of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, TaiwanDepartment of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, TaiwanDepartment of Veterinary Medicine, National Chiayi University, 580 Xinmin Road, Chiayi 60054, TaiwanDepartment of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, 1, Shuefu Road, Neipu, Pingtung 912301, TaiwanObesity-associated hyperglycemia underlies insulin resistance, glucose intolerance, and related metabolic disorders including type 2 diabetes, renal damage, and nonalcoholic fatty liver disease. Turmeric root is commonly used in Asia, and curcumin, one of its pharmacological components, can play a role in preventing and treating certain chronic physiological disorders. Accordingly, this study examined how high-fat diet (HFD)-induced hyperglycemia and hyperlipidemia are reduced by curcumin through changes in fatty liver scores, chromium distribution, and renal injury in mice. Relative to the control group, also fed an HFD, the curcumin group weighed less and had smaller adipocytes; it also had lower daily food efficiency, blood urea nitrogen and creatinine levels, serum alanine aminotransferase and aspartate aminotransferase levels, serum and hepatic triglyceride levels, and hepatic lipid regulation marker expression. The curcumin-treated obese group exhibited significantly lower fasting blood glucose, was less glucose intolerant, had higher Akt phosphorylation and glucose transporter 4 (GLUT4) expression, and had greater serum insulin levels. Moreover, the group showed renal damage with lower TNF-α expression along with more numerous renal antioxidative enzymes that included superoxide dismutase, glutathione peroxidase, and catalase. The liver histology of the curcumin-treated obese mice showed superior lipid infiltration and fewer FASN and PNPLA3 proteins in comparison with the control mice. Curcumin contributed to creating a positive chromium balance by decreasing the amount of chromium lost through urine, leading to the chromium mobilization needed to mitigate hyperglycemia. Thus, the results suggest that curcumin prevents HFD-induced glucose intolerance, kidney injury, and nonalcoholic fatty liver disease.https://www.mdpi.com/2227-9717/9/7/1132curcuminchromiumfatty liverglucose intolerancerenal injuryobesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Geng-Ruei Chang Wen-Tsong Hsieh Lan-Szu Chou Chen-Si Lin Ching-Fen Wu Jen-Wei Lin Wei-Li Lin Tzu-Chun Lin Huei-Jyuan Liao Chen-Yung Kao Chuen-Fu Lin |
spellingShingle |
Geng-Ruei Chang Wen-Tsong Hsieh Lan-Szu Chou Chen-Si Lin Ching-Fen Wu Jen-Wei Lin Wei-Li Lin Tzu-Chun Lin Huei-Jyuan Liao Chen-Yung Kao Chuen-Fu Lin Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese Mice Processes curcumin chromium fatty liver glucose intolerance renal injury obesity |
author_facet |
Geng-Ruei Chang Wen-Tsong Hsieh Lan-Szu Chou Chen-Si Lin Ching-Fen Wu Jen-Wei Lin Wei-Li Lin Tzu-Chun Lin Huei-Jyuan Liao Chen-Yung Kao Chuen-Fu Lin |
author_sort |
Geng-Ruei Chang |
title |
Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese Mice |
title_short |
Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese Mice |
title_full |
Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese Mice |
title_fullStr |
Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese Mice |
title_full_unstemmed |
Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese Mice |
title_sort |
curcumin improved glucose intolerance, renal injury, and nonalcoholic fatty liver disease and decreased chromium loss through urine in obese mice |
publisher |
MDPI AG |
series |
Processes |
issn |
2227-9717 |
publishDate |
2021-06-01 |
description |
Obesity-associated hyperglycemia underlies insulin resistance, glucose intolerance, and related metabolic disorders including type 2 diabetes, renal damage, and nonalcoholic fatty liver disease. Turmeric root is commonly used in Asia, and curcumin, one of its pharmacological components, can play a role in preventing and treating certain chronic physiological disorders. Accordingly, this study examined how high-fat diet (HFD)-induced hyperglycemia and hyperlipidemia are reduced by curcumin through changes in fatty liver scores, chromium distribution, and renal injury in mice. Relative to the control group, also fed an HFD, the curcumin group weighed less and had smaller adipocytes; it also had lower daily food efficiency, blood urea nitrogen and creatinine levels, serum alanine aminotransferase and aspartate aminotransferase levels, serum and hepatic triglyceride levels, and hepatic lipid regulation marker expression. The curcumin-treated obese group exhibited significantly lower fasting blood glucose, was less glucose intolerant, had higher Akt phosphorylation and glucose transporter 4 (GLUT4) expression, and had greater serum insulin levels. Moreover, the group showed renal damage with lower TNF-α expression along with more numerous renal antioxidative enzymes that included superoxide dismutase, glutathione peroxidase, and catalase. The liver histology of the curcumin-treated obese mice showed superior lipid infiltration and fewer FASN and PNPLA3 proteins in comparison with the control mice. Curcumin contributed to creating a positive chromium balance by decreasing the amount of chromium lost through urine, leading to the chromium mobilization needed to mitigate hyperglycemia. Thus, the results suggest that curcumin prevents HFD-induced glucose intolerance, kidney injury, and nonalcoholic fatty liver disease. |
topic |
curcumin chromium fatty liver glucose intolerance renal injury obesity |
url |
https://www.mdpi.com/2227-9717/9/7/1132 |
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