Presenilin-1 Mutations Are a Cause of Primary Lateral Sclerosis-Like Syndrome

Presenilin-1 Mutations Are a Cause of Primary Lateral Sclerosis-Like Syndrome

Background and PurposePrimary lateral sclerosis (PLS) is a progressive upper motor neuron (UMN) disorder. It is debated whether PLS is part of the amyotrophic lateral sclerosis (ALS) spectrum, or a syndrome encompassing different neurodegenerative diseases. Recently, new diagnostic criteria for PLS...

Full description

Bibliographic Details
Main Authors: Juan Francisco Vázquez-Costa, María Payá-Montes, Marina Martínez-Molina, Teresa Jaijo, Jazek Szymanski, Miguel Mazón, Pablo Sopena-Novales, ENoD Consortium, Jordi Pérez-Tur, Teresa Sevilla, Beatriz Morte, Rosario Carmona, Javier Perez-Florido, Virginia Aquino, Francisco Ortuño, Daniel Lopez-Lopez, Gerrit Bostelmann, Joaquin Dopazo, Luis Alberto Pérez-Jurado
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
primary lateral sclerosis
progressive spastic paraparesis
Alzheimer’s disease
PSEN1 mutation
motor neuron disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.721047/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.721047/full

Similar Items