Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters
The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models...
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Nature Publishing Group
2019-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12702-8 |
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doaj-fe549d39d8134e549baba3508cc6c30c2021-05-11T12:21:26ZengNature Publishing GroupNature Communications2041-17232019-10-0110111410.1038/s41467-019-12702-8Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persistersKaixi Zhang0Yu Du1Zhangyong Si2Yang Liu3Michelle E. Turvey4Cheerlavancha Raju5Damien Keogh6Lin Ruan7Subramanion L. Jothy8Sheethal Reghu9Kalisvar Marimuthu10Partha Pratim De11Oon Tek Ng12José R. Mediavilla13Barry N. Kreiswirth14Yonggui Robin Chi15Jinghua Ren16Kam C. Tam17Xue-Wei Liu18Hongwei Duan19Yabin Zhu20Yuguang Mu21Paula T. Hammond22Guillermo C. Bazan23Kevin Pethe24Mary B. Chan-Park25School of Chemical and Biomedical Engineering, Nanyang Technological UniversitySchool of Chemical and Biomedical Engineering, Nanyang Technological UniversitySchool of Chemical and Biomedical Engineering, Nanyang Technological UniversityCentre for Antimicrobial Bioengineering, Nanyang Technological UniversityInfectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research & Technology CentreSchool of Chemical and Biomedical Engineering, Nanyang Technological UniversitySchool of Chemical and Biomedical Engineering, Nanyang Technological UniversitySchool of Chemical and Biomedical Engineering, Nanyang Technological UniversitySchool of Chemical and Biomedical Engineering, Nanyang Technological UniversitySchool of Chemical and Biomedical Engineering, Nanyang Technological UniversityDepartment of Infectious Diseases, Tan Tock Seng HospitalDepartment of Laboratory Medicine, Tan Tock Seng HospitalDepartment of Infectious Diseases, Tan Tock Seng HospitalCenter for Discovery and Innovation, Hackensack Meridian HealthCenter for Discovery and Innovation, Hackensack Meridian HealthDivision of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological UniversityCancer Center, Union Hospital, Huazhong University of Science & TechnologyDepartment of Chemical Engineering, Waterloo Institute for Nanotechnology, University of WaterlooCentre for Antimicrobial Bioengineering, Nanyang Technological UniversitySchool of Chemical and Biomedical Engineering, Nanyang Technological UniversityMedical School of Ningbo University, NingboSchool of Biological Sciences, Nanyang Technological UniversityKoch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyDepartment of Chemistry and Biochemistry, University of California Santa BarbaraCentre for Antimicrobial Bioengineering, Nanyang Technological UniversitySchool of Chemical and Biomedical Engineering, Nanyang Technological UniversityThe authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity.https://doi.org/10.1038/s41467-019-12702-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kaixi Zhang Yu Du Zhangyong Si Yang Liu Michelle E. Turvey Cheerlavancha Raju Damien Keogh Lin Ruan Subramanion L. Jothy Sheethal Reghu Kalisvar Marimuthu Partha Pratim De Oon Tek Ng José R. Mediavilla Barry N. Kreiswirth Yonggui Robin Chi Jinghua Ren Kam C. Tam Xue-Wei Liu Hongwei Duan Yabin Zhu Yuguang Mu Paula T. Hammond Guillermo C. Bazan Kevin Pethe Mary B. Chan-Park |
| spellingShingle |
Kaixi Zhang Yu Du Zhangyong Si Yang Liu Michelle E. Turvey Cheerlavancha Raju Damien Keogh Lin Ruan Subramanion L. Jothy Sheethal Reghu Kalisvar Marimuthu Partha Pratim De Oon Tek Ng José R. Mediavilla Barry N. Kreiswirth Yonggui Robin Chi Jinghua Ren Kam C. Tam Xue-Wei Liu Hongwei Duan Yabin Zhu Yuguang Mu Paula T. Hammond Guillermo C. Bazan Kevin Pethe Mary B. Chan-Park Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters Nature Communications |
| author_facet |
Kaixi Zhang Yu Du Zhangyong Si Yang Liu Michelle E. Turvey Cheerlavancha Raju Damien Keogh Lin Ruan Subramanion L. Jothy Sheethal Reghu Kalisvar Marimuthu Partha Pratim De Oon Tek Ng José R. Mediavilla Barry N. Kreiswirth Yonggui Robin Chi Jinghua Ren Kam C. Tam Xue-Wei Liu Hongwei Duan Yabin Zhu Yuguang Mu Paula T. Hammond Guillermo C. Bazan Kevin Pethe Mary B. Chan-Park |
| author_sort |
Kaixi Zhang |
| title |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_short |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_full |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_fullStr |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_full_unstemmed |
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| title_sort |
enantiomeric glycosylated cationic block co-beta-peptides eradicate staphylococcus aureus biofilms and antibiotic-tolerant persisters |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-10-01 |
| description |
The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms. The copolymer displays antibacterial activity in human ex vivo and mouse in vivo infection models without toxicity. |
| url |
https://doi.org/10.1038/s41467-019-12702-8 |
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