Study on sEng, VEGF, PLGF, and sFlt-1 levels, and umbilical artery blood flow change in the pregnant women with preeclampsia

• Main Author: Xia Liu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-04-01
• Series: Journal of Hainan Medical University
• Subjects: PE; sEng; VEGF; sFlt-1; PLGF; Umbilical artery blood flow
• Online Access: http://www.hnykdxxb.com/PDF/201608/14.pdf

Objective: To observe sEng, VEGF, PLGF, and sFlt-1 levels, and umbilical artery blood flow change in the pregnant women with preeclampsia (PE), and their clinical significance. Methods: A total of 60 pregnant women with moderate and severe PE who were admitted in our hospital from January, 2014 to April, 2015 were included in the study and divided into the observation group 1 and observation group 2 with 30 cases in each group. ELISA was used to detect the levels of serum sEng, VEGF, PLGF, and sFlt-1. The color Doppler Ultrasound Diagnosis Apparatus was used to detect the changes of S/D, and RI. A total of 30 pregnant women who came for antenatal examination at the same period were served as the control group. Results:The levels of serum sEng, and sFlt-1 in the observation group 1 and 2 were significantly higher than those in the control group. The levels of serum sEng, and sFlt-1 in the observation group 2 were significantly higher than those in the observation group 1. The levels of serum VEGF and PLGF in the observation group 1 and 2 were significantly lower than those in the control group. The levels of serum VEGF and PLGF in the observation group were significantly lower than those in the observation group 1. S/D, and RI in the observation group 1 and 2 were significantly higher than those in the control group. S/D, and RI in the observation group 2 were significantly higher than those in the observation group 1. Conclusions: The serum sEng, VEGF, PLGF, and sFlt-1 levels are associated with PE, detection of which can accurately estimate the severity degree of PE, and determination of the umbilical artery blood flow can also accurately reflect PE condition.