The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis.
KRAS mutation has been found in various types of cancer. However, the prognostic value of KRAS mutation in cell-free DNA (cfDNA) in cancer patients was conflicting. In the present study, a meta-analysis was conducted to clarify its prognostic significance. Literature searches of Cochrane Library, EM...
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doaj-fe553df5757c4d1791b46b2df4c4b9aa2020-11-25T01:31:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018256210.1371/journal.pone.0182562The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis.Rongyuan ZhuangSong LiQian LiXi GuoFeng ShenHong SunTianshu LiuKRAS mutation has been found in various types of cancer. However, the prognostic value of KRAS mutation in cell-free DNA (cfDNA) in cancer patients was conflicting. In the present study, a meta-analysis was conducted to clarify its prognostic significance. Literature searches of Cochrane Library, EMBASE, PubMed and Web of Science were performed to identify studies related to KRAS mutation detected by cfDNA and survival in cancer patients. Two evaluators reviewed and extracted the information independently. Review Manager 5.3 software was used to perform the statistical analysis. Thirty studies were included in the present meta-analysis. Our analysis showed that KRAS mutation in cfDNA was associated with a poorer survival in cancer patients for overall survival (OS, HR 2.02, 95% CI 1.63-2.51, P<0.01) and progression-free survival (PFS, HR 1.64, 95% CI 1.27-2.13, P<0.01). In subgroup analyses, KRAS mutation in pancreatic cancer, colorectal cancer, non-small cell lung cancer and ovarian epithelial cancer had HRs of 2.81 (95% CI 1.83-4.30, P<0.01), 1.67 (95% CI 1.25-2.42, P<0.01), 1.64 (95% CI 1.13-2.39, P = 0.01) and 2.17 (95% 1.12-4.21, p = 0.02) for OS, respectively. In addition, the ethnicity didn't influence the prognostic value of KRAS mutation in cfDNA in cancer patients (p = 0.39). Prognostic value of KRAS mutation was slightly higher in plasma than in serum (HR 2.13 vs 1.65), but no difference was observed (p = 0.37). Briefly, KRAS mutation in cfDNA was a survival prognostic biomarker in cancer patients. Its prognostic value was different in various types of cancer.http://europepmc.org/articles/PMC5552123?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rongyuan Zhuang Song Li Qian Li Xi Guo Feng Shen Hong Sun Tianshu Liu |
spellingShingle |
Rongyuan Zhuang Song Li Qian Li Xi Guo Feng Shen Hong Sun Tianshu Liu The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis. PLoS ONE |
author_facet |
Rongyuan Zhuang Song Li Qian Li Xi Guo Feng Shen Hong Sun Tianshu Liu |
author_sort |
Rongyuan Zhuang |
title |
The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis. |
title_short |
The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis. |
title_full |
The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis. |
title_fullStr |
The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis. |
title_full_unstemmed |
The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis. |
title_sort |
prognostic value of kras mutation by cell-free dna in cancer patients: a systematic review and meta-analysis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
KRAS mutation has been found in various types of cancer. However, the prognostic value of KRAS mutation in cell-free DNA (cfDNA) in cancer patients was conflicting. In the present study, a meta-analysis was conducted to clarify its prognostic significance. Literature searches of Cochrane Library, EMBASE, PubMed and Web of Science were performed to identify studies related to KRAS mutation detected by cfDNA and survival in cancer patients. Two evaluators reviewed and extracted the information independently. Review Manager 5.3 software was used to perform the statistical analysis. Thirty studies were included in the present meta-analysis. Our analysis showed that KRAS mutation in cfDNA was associated with a poorer survival in cancer patients for overall survival (OS, HR 2.02, 95% CI 1.63-2.51, P<0.01) and progression-free survival (PFS, HR 1.64, 95% CI 1.27-2.13, P<0.01). In subgroup analyses, KRAS mutation in pancreatic cancer, colorectal cancer, non-small cell lung cancer and ovarian epithelial cancer had HRs of 2.81 (95% CI 1.83-4.30, P<0.01), 1.67 (95% CI 1.25-2.42, P<0.01), 1.64 (95% CI 1.13-2.39, P = 0.01) and 2.17 (95% 1.12-4.21, p = 0.02) for OS, respectively. In addition, the ethnicity didn't influence the prognostic value of KRAS mutation in cfDNA in cancer patients (p = 0.39). Prognostic value of KRAS mutation was slightly higher in plasma than in serum (HR 2.13 vs 1.65), but no difference was observed (p = 0.37). Briefly, KRAS mutation in cfDNA was a survival prognostic biomarker in cancer patients. Its prognostic value was different in various types of cancer. |
url |
http://europepmc.org/articles/PMC5552123?pdf=render |
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