The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats
Abstract Background Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP). In addition, metabotropic glutamate receptors (mGluRs) in NAc play important roles in the reward path...
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doaj-fe58af9f164a440991ffd186ffa90fe72021-03-21T12:52:16ZengBMCBMC Neuroscience1471-22022021-03-0122111010.1186/s12868-021-00627-2The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male ratsZahra Ebrahimi0Nazanin Kahvandi1Alireza Komaki2Seyed Asaad Karimi3Marzieh Naderishahab4Abdolrahman Sarihi5Neurophysiology Research Center, Hamadan University of Medical SciencesDepartment of Physiology, Faculty of Medicine, Hamadan University of Medical SciencesNeurophysiology Research Center, Hamadan University of Medical SciencesNeurophysiology Research Center, Hamadan University of Medical SciencesNeurophysiology Research Center, Hamadan University of Medical SciencesNeurophysiology Research Center, Hamadan University of Medical SciencesAbstract Background Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP). In addition, metabotropic glutamate receptors (mGluRs) in NAc play important roles in the reward pathways. However, the precise role of mGluR4 in different steps of the morphine-induced CPP is less well known. In the present study the effect of bilateral intra-accumbal infusion of VU0155041, as a specific mGluR4 agonist on the acquisition and expression of morphine induced CPP in male Wistar rats was investigated. The animals were bilaterally implanted with guide cannulae above the NAc. In the first step of the study, the VU0155041 was administered at doses of 10, 30 and 50 μg/0.5 μL saline per side into the NAc during the 3 days of morphine (5 mg/kg) conditioning (acquisition) phase of morphine-induced CPP. In the second step of the study, the rats bilaterally received VU0155041 at the dose of 50 μg/0.5 μL, 5 min before the post-conditioning test in order to check the effect of VU0155041 on the expression of morphine-induced CPP. Results The results showed that the intra-accumbal injection of VU0155041 inhibits the acquisition of morphine-induced CPP in a dose dependent manner, but had no effect on expression. Conclusions The data indicated that intra-NAc administration of VU0155041 dose dependently blocks the establishment of morphine-induced CPP and reduces the rewarding properties of morphine. These effects may be related to changes in glutamate activity in the NAC and/or learning dependent mechanism of glutamate neurotransmission in reward pathway(s).https://doi.org/10.1186/s12868-021-00627-2Metabotropic glutamate receptor type 4Nucleus accumbensConditioned place preferenceMorphineRat |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zahra Ebrahimi Nazanin Kahvandi Alireza Komaki Seyed Asaad Karimi Marzieh Naderishahab Abdolrahman Sarihi |
spellingShingle |
Zahra Ebrahimi Nazanin Kahvandi Alireza Komaki Seyed Asaad Karimi Marzieh Naderishahab Abdolrahman Sarihi The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats BMC Neuroscience Metabotropic glutamate receptor type 4 Nucleus accumbens Conditioned place preference Morphine Rat |
author_facet |
Zahra Ebrahimi Nazanin Kahvandi Alireza Komaki Seyed Asaad Karimi Marzieh Naderishahab Abdolrahman Sarihi |
author_sort |
Zahra Ebrahimi |
title |
The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats |
title_short |
The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats |
title_full |
The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats |
title_fullStr |
The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats |
title_full_unstemmed |
The role of mGlu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats |
title_sort |
role of mglu4 receptors within the nucleus accumbens in acquisition and expression of morphine-induced conditioned place preference in male rats |
publisher |
BMC |
series |
BMC Neuroscience |
issn |
1471-2202 |
publishDate |
2021-03-01 |
description |
Abstract Background Several studies have shown that glutamate neurotransmission in the nucleus accumbens (NAc) is required for the development of morphine-induced conditional place preference (CPP). In addition, metabotropic glutamate receptors (mGluRs) in NAc play important roles in the reward pathways. However, the precise role of mGluR4 in different steps of the morphine-induced CPP is less well known. In the present study the effect of bilateral intra-accumbal infusion of VU0155041, as a specific mGluR4 agonist on the acquisition and expression of morphine induced CPP in male Wistar rats was investigated. The animals were bilaterally implanted with guide cannulae above the NAc. In the first step of the study, the VU0155041 was administered at doses of 10, 30 and 50 μg/0.5 μL saline per side into the NAc during the 3 days of morphine (5 mg/kg) conditioning (acquisition) phase of morphine-induced CPP. In the second step of the study, the rats bilaterally received VU0155041 at the dose of 50 μg/0.5 μL, 5 min before the post-conditioning test in order to check the effect of VU0155041 on the expression of morphine-induced CPP. Results The results showed that the intra-accumbal injection of VU0155041 inhibits the acquisition of morphine-induced CPP in a dose dependent manner, but had no effect on expression. Conclusions The data indicated that intra-NAc administration of VU0155041 dose dependently blocks the establishment of morphine-induced CPP and reduces the rewarding properties of morphine. These effects may be related to changes in glutamate activity in the NAC and/or learning dependent mechanism of glutamate neurotransmission in reward pathway(s). |
topic |
Metabotropic glutamate receptor type 4 Nucleus accumbens Conditioned place preference Morphine Rat |
url |
https://doi.org/10.1186/s12868-021-00627-2 |
work_keys_str_mv |
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