Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis

We present a rare case of a 23-year-old male incidentally detected with hepatitis B virus (HBV) infection presenting with features suggestive of HBV-associated nephropathy. A renal biopsy specimen suggested a mesangioproliferative glomerulonephritis with a full-house pattern on immunoflourescence co...

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Main Authors: Amitesh Aggarwal, Mukul P Agarwal, Surendra Rajpal, Vineeta V Batra, Ankit Kumar Sahu
Format: Article
Language:English
Published: SMC MEDIA SRL 2014-04-01
Series:European Journal of Case Reports in Internal Medicine
Subjects:
Online Access:http://ejcrim.com/index.php/EJCRIM/article/view/40
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spelling doaj-fe683129738f49629af4c6769227e7fa2020-11-25T00:17:55ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942014-04-011110.12890/2014_00004024Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus NephritisAmitesh Aggarwal0Mukul P Agarwal1Surendra Rajpal2Vineeta V Batra3Ankit Kumar Sahu4Department of Medicine, University College of Medical Sciences & GTB Hospital, DelhiDepartment of Medicine, University College of Medical Sciences & GTB Hospital, DelhiDepartment of Medicine, University College of Medical Sciences & GTB Hospital, DelhiDepartment of Pathology, Govind Ballabh Pant hospital, New DelhiDepartment of Medicine, University College of Medical Sciences & GTB Hospital, Delhi,We present a rare case of a 23-year-old male incidentally detected with hepatitis B virus (HBV) infection presenting with features suggestive of HBV-associated nephropathy. A renal biopsy specimen suggested a mesangioproliferative glomerulonephritis with a full-house pattern on immunoflourescence consistent with a diagnosis of diffuse lupus nephritis. Glomerular HbeAg and HbsAg antigens were not detectable by immunofluorescence. Antiviral therapy was instituted to suppress viral replication, thereby leading to clinical and virological remission, including that of the glomerulonephritis, without the need for additional immunosuppressant therapy. This case depicts the uniqueness of the presentation of the two conditions mimicking each other, the strategy adopted to prevent the activation of viral replication and the achievement of clinical remission.http://ejcrim.com/index.php/EJCRIM/article/view/40Hepatitis B, HBV-associated nephropathy, lupus nephritis
collection DOAJ
language English
format Article
sources DOAJ
author Amitesh Aggarwal
Mukul P Agarwal
Surendra Rajpal
Vineeta V Batra
Ankit Kumar Sahu
spellingShingle Amitesh Aggarwal
Mukul P Agarwal
Surendra Rajpal
Vineeta V Batra
Ankit Kumar Sahu
Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis
European Journal of Case Reports in Internal Medicine
Hepatitis B, HBV-associated nephropathy, lupus nephritis
author_facet Amitesh Aggarwal
Mukul P Agarwal
Surendra Rajpal
Vineeta V Batra
Ankit Kumar Sahu
author_sort Amitesh Aggarwal
title Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis
title_short Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis
title_full Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis
title_fullStr Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis
title_full_unstemmed Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis
title_sort chronic active hepatitis b with hbv-associated nephropathy: close resemblance to lupus nephritis
publisher SMC MEDIA SRL
series European Journal of Case Reports in Internal Medicine
issn 2284-2594
publishDate 2014-04-01
description We present a rare case of a 23-year-old male incidentally detected with hepatitis B virus (HBV) infection presenting with features suggestive of HBV-associated nephropathy. A renal biopsy specimen suggested a mesangioproliferative glomerulonephritis with a full-house pattern on immunoflourescence consistent with a diagnosis of diffuse lupus nephritis. Glomerular HbeAg and HbsAg antigens were not detectable by immunofluorescence. Antiviral therapy was instituted to suppress viral replication, thereby leading to clinical and virological remission, including that of the glomerulonephritis, without the need for additional immunosuppressant therapy. This case depicts the uniqueness of the presentation of the two conditions mimicking each other, the strategy adopted to prevent the activation of viral replication and the achievement of clinical remission.
topic Hepatitis B, HBV-associated nephropathy, lupus nephritis
url http://ejcrim.com/index.php/EJCRIM/article/view/40
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AT surendrarajpal chronicactivehepatitisbwithhbvassociatednephropathycloseresemblancetolupusnephritis
AT vineetavbatra chronicactivehepatitisbwithhbvassociatednephropathycloseresemblancetolupusnephritis
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