Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)

Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)

Genome-wide association studies (GWAS) have identified an abundance of genetic loci associated with complex traits and diseases. In contrast, in-depth characterization of an individual genetic signal is rarely available. Here, we focus on the genetic variant rs2168518 in 15q24.1 previously associate...

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Bibliographic Details
Main Authors: Christina Kiel, Tobias Strunz, International AMD Genomics Consortium (Project Manager Susan Blanton) IAMDGC, Felix Grassmann, Bernhard H.F. Weber
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
age-related macular degeneration
choroidal neovascularization
pleiotropy
miRNA variant
eQTL
locus analysis
Online Access:https://www.mdpi.com/2073-4409/9/10/2257

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