In Vitro and in Vivo Effects of Three Different Mitragyna speciosa Korth Leaf Extracts on Phase II Drug Metabolizing Enzymes—Glutathione Transferases (GSTs)

In Vitro and in Vivo Effects of Three Different Mitragyna speciosa Korth Leaf Extracts on Phase II Drug Metabolizing Enzymes—Glutathione Transferases (GSTs)

In the present study, we investigate the effects of three different Mitragyna speciosa extracts, namely methanolic, aqueous and total alkaloid extracts, on glutathione transferase-specific activity in male Sprague Dawley rat liver cytosol in vitro and in vivo. In the in vitro study, the effect of Mi...

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Bibliographic Details
Main Authors: Sharif Mahsufi Mansor, Mohd Ikram Mohd Said, Surash Ramanathan, Mohd Nizam Mordi, Sabariah Ismail, Juzaili Azizi
Format: Article
Language:English
Published: MDPI AG 2010-01-01
Series:Molecules
Subjects:
herb-drug interactions
glutathione transferases
Mitragyna speciosa
in vitro
in vivo
Online Access:http://www.mdpi.com/1420-3049/15/1/432/

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