Platelet Membrane Receptor Proteolysis: Implications for Platelet Function
The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. The proteases involved are of different ori...
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doaj-fe762e6d8e0c48e6a0f221e9702e40f92021-01-08T04:45:13ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-01-01710.3389/fcvm.2020.608391608391Platelet Membrane Receptor Proteolysis: Implications for Platelet FunctionJiayu Wu0Johan W. M. Heemskerk1Constance C. F. M. J. Baaten2Constance C. F. M. J. Baaten3Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, NetherlandsDepartment of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, NetherlandsDepartment of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, NetherlandsInstitute for Molecular Cardiovascular Research (IMCAR), University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, GermanyThe activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. We provide a comprehensive overview of the proteases acting on the platelet membrane. We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. The review focuses on coagulation-related proteases, plasmin, matrix metalloproteinases, ADAM(TS) isoforms, cathepsins, caspases, and calpains. We also describe how the proteolytic activities are determined by different platelet populations in a thrombus and conversely how proteolysis contributes to the formation of such populations.https://www.frontiersin.org/articles/10.3389/fcvm.2020.608391/fullADAMcalpaincaspasecoagulation factorsMMPplatelets |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiayu Wu Johan W. M. Heemskerk Constance C. F. M. J. Baaten Constance C. F. M. J. Baaten |
spellingShingle |
Jiayu Wu Johan W. M. Heemskerk Constance C. F. M. J. Baaten Constance C. F. M. J. Baaten Platelet Membrane Receptor Proteolysis: Implications for Platelet Function Frontiers in Cardiovascular Medicine ADAM calpain caspase coagulation factors MMP platelets |
author_facet |
Jiayu Wu Johan W. M. Heemskerk Constance C. F. M. J. Baaten Constance C. F. M. J. Baaten |
author_sort |
Jiayu Wu |
title |
Platelet Membrane Receptor Proteolysis: Implications for Platelet Function |
title_short |
Platelet Membrane Receptor Proteolysis: Implications for Platelet Function |
title_full |
Platelet Membrane Receptor Proteolysis: Implications for Platelet Function |
title_fullStr |
Platelet Membrane Receptor Proteolysis: Implications for Platelet Function |
title_full_unstemmed |
Platelet Membrane Receptor Proteolysis: Implications for Platelet Function |
title_sort |
platelet membrane receptor proteolysis: implications for platelet function |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2021-01-01 |
description |
The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. We provide a comprehensive overview of the proteases acting on the platelet membrane. We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. The review focuses on coagulation-related proteases, plasmin, matrix metalloproteinases, ADAM(TS) isoforms, cathepsins, caspases, and calpains. We also describe how the proteolytic activities are determined by different platelet populations in a thrombus and conversely how proteolysis contributes to the formation of such populations. |
topic |
ADAM calpain caspase coagulation factors MMP platelets |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2020.608391/full |
work_keys_str_mv |
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