Complex Roles of Neutrophils during Arboviral Infections
Arboviruses are known to cause large-scale epidemics in many parts of the world. These arthropod-borne viruses are a large group consisting of viruses from a wide range of families. The ability of their vector to enhance viral pathogenesis and transmission makes the development of treatments against...
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doaj-fe8096cfcf4849d7a5f7f16969f205262021-06-01T01:12:46ZengMDPI AGCells2073-44092021-05-01101324132410.3390/cells10061324Complex Roles of Neutrophils during Arboviral InfectionsAbenaya Muralidharan0St Patrick Reid1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900, USADepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900, USAArboviruses are known to cause large-scale epidemics in many parts of the world. These arthropod-borne viruses are a large group consisting of viruses from a wide range of families. The ability of their vector to enhance viral pathogenesis and transmission makes the development of treatments against these viruses challenging. Neutrophils are generally the first leukocytes to be recruited to a site of infection, playing a major role in regulating inflammation and, as a result, viral replication and dissemination. However, the underlying mechanisms through which neutrophils control the progression of inflammation and disease remain to be fully understood. In this review, we highlight the major findings from recent years regarding the role of neutrophils during arboviral infections. We discuss the complex nature of neutrophils in mediating not only protection, but also augmenting disease pathology. Better understanding of neutrophil pathways involved in effective protection against arboviral infections can help identify potential targets for therapeutics.https://www.mdpi.com/2073-4409/10/6/1324neutrophilsarbovirusesmosquitoinflammationpathology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abenaya Muralidharan St Patrick Reid |
spellingShingle |
Abenaya Muralidharan St Patrick Reid Complex Roles of Neutrophils during Arboviral Infections Cells neutrophils arboviruses mosquito inflammation pathology |
author_facet |
Abenaya Muralidharan St Patrick Reid |
author_sort |
Abenaya Muralidharan |
title |
Complex Roles of Neutrophils during Arboviral Infections |
title_short |
Complex Roles of Neutrophils during Arboviral Infections |
title_full |
Complex Roles of Neutrophils during Arboviral Infections |
title_fullStr |
Complex Roles of Neutrophils during Arboviral Infections |
title_full_unstemmed |
Complex Roles of Neutrophils during Arboviral Infections |
title_sort |
complex roles of neutrophils during arboviral infections |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2021-05-01 |
description |
Arboviruses are known to cause large-scale epidemics in many parts of the world. These arthropod-borne viruses are a large group consisting of viruses from a wide range of families. The ability of their vector to enhance viral pathogenesis and transmission makes the development of treatments against these viruses challenging. Neutrophils are generally the first leukocytes to be recruited to a site of infection, playing a major role in regulating inflammation and, as a result, viral replication and dissemination. However, the underlying mechanisms through which neutrophils control the progression of inflammation and disease remain to be fully understood. In this review, we highlight the major findings from recent years regarding the role of neutrophils during arboviral infections. We discuss the complex nature of neutrophils in mediating not only protection, but also augmenting disease pathology. Better understanding of neutrophil pathways involved in effective protection against arboviral infections can help identify potential targets for therapeutics. |
topic |
neutrophils arboviruses mosquito inflammation pathology |
url |
https://www.mdpi.com/2073-4409/10/6/1324 |
work_keys_str_mv |
AT abenayamuralidharan complexrolesofneutrophilsduringarboviralinfections AT stpatrickreid complexrolesofneutrophilsduringarboviralinfections |
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1721412934903529472 |