Mirtazapine versus fluoxetine in the treatment of panic disorder
Mirtazapine is an antidepressant whose side effect profile differs from that of first-line agents (selective serotonin reuptake inhibitors) used in the treatment of panic disorder. The present study compared the effect of mirtazapine and fluoxetine in the treatment of panic disorder in a double-blin...
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Associação Brasileira de Divulgação Científica
2001-10-01
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doaj-fe87c45c43244b2cab675fc8bd694ee92020-11-24T22:37:55ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2001-10-0134101303130710.1590/S0100-879X2001001000010Mirtazapine versus fluoxetine in the treatment of panic disorderL. RibeiroJ.V. BusnelloM. Kauer-Sant'AnnaM. MadrugaJ. QuevedoE.A.D. BusnelloF. KapczinskiMirtazapine is an antidepressant whose side effect profile differs from that of first-line agents (selective serotonin reuptake inhibitors) used in the treatment of panic disorder. The present study compared the effect of mirtazapine and fluoxetine in the treatment of panic disorder in a double-blind, randomized, flexible-dose trial conducted with outpatients. After a 1-week single-blind placebo run-in, 27 patients entered an 8-week double-blind phase in which they were randomly assigned to treatment with either mirtazapine or fluoxetine. Both groups improved significantly in all but one efficacy measure (P<=0.01). ANOVA showed no significant differences between the two treatment groups in number of panic attacks, Hamilton Anxiety Scale or Sheehan Phobic Scale, whereas measures of patient global evaluation of phobic anxiety were significantly different between groups (F1,20 = 6.91, P = 0.016) favoring mirtazapine. For the 22 patients who completed the study, the mean daily dose of mirtazapine was 18.3 ± 1.3 vs 14.0 ± 1.0 mg for fluoxetine at the endpoint. Weight gain occurred more frequently in the mirtazapine group (50 vs 7.7%, P = 0.04) and nausea and paresthesia occurred more often in the fluoxetine group (P = 0.01). Results suggest that mirtazapine has properties that make it attractive for the treatment of panic disorder.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000010mirtazapinefluoxetinepanic disordertreatmentrandomized trial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
L. Ribeiro J.V. Busnello M. Kauer-Sant'Anna M. Madruga J. Quevedo E.A.D. Busnello F. Kapczinski |
spellingShingle |
L. Ribeiro J.V. Busnello M. Kauer-Sant'Anna M. Madruga J. Quevedo E.A.D. Busnello F. Kapczinski Mirtazapine versus fluoxetine in the treatment of panic disorder Brazilian Journal of Medical and Biological Research mirtazapine fluoxetine panic disorder treatment randomized trial |
author_facet |
L. Ribeiro J.V. Busnello M. Kauer-Sant'Anna M. Madruga J. Quevedo E.A.D. Busnello F. Kapczinski |
author_sort |
L. Ribeiro |
title |
Mirtazapine versus fluoxetine in the treatment of panic disorder |
title_short |
Mirtazapine versus fluoxetine in the treatment of panic disorder |
title_full |
Mirtazapine versus fluoxetine in the treatment of panic disorder |
title_fullStr |
Mirtazapine versus fluoxetine in the treatment of panic disorder |
title_full_unstemmed |
Mirtazapine versus fluoxetine in the treatment of panic disorder |
title_sort |
mirtazapine versus fluoxetine in the treatment of panic disorder |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 1414-431X |
publishDate |
2001-10-01 |
description |
Mirtazapine is an antidepressant whose side effect profile differs from that of first-line agents (selective serotonin reuptake inhibitors) used in the treatment of panic disorder. The present study compared the effect of mirtazapine and fluoxetine in the treatment of panic disorder in a double-blind, randomized, flexible-dose trial conducted with outpatients. After a 1-week single-blind placebo run-in, 27 patients entered an 8-week double-blind phase in which they were randomly assigned to treatment with either mirtazapine or fluoxetine. Both groups improved significantly in all but one efficacy measure (P<=0.01). ANOVA showed no significant differences between the two treatment groups in number of panic attacks, Hamilton Anxiety Scale or Sheehan Phobic Scale, whereas measures of patient global evaluation of phobic anxiety were significantly different between groups (F1,20 = 6.91, P = 0.016) favoring mirtazapine. For the 22 patients who completed the study, the mean daily dose of mirtazapine was 18.3 ± 1.3 vs 14.0 ± 1.0 mg for fluoxetine at the endpoint. Weight gain occurred more frequently in the mirtazapine group (50 vs 7.7%, P = 0.04) and nausea and paresthesia occurred more often in the fluoxetine group (P = 0.01). Results suggest that mirtazapine has properties that make it attractive for the treatment of panic disorder. |
topic |
mirtazapine fluoxetine panic disorder treatment randomized trial |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000010 |
work_keys_str_mv |
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