Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification
Abstract In this study, we report antibacterial activity of metalloporphyrins; 5, 10, 15, 20-tetrakis (para-X phenyl)porphyrinato M (II) [where X = H, NH2 and COOMe for M = Cu and X = COOH and OMe for M = Co]. The activity study of the as-synthesized metalloporphyrins toward two Gram-positive (S. a...
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doaj-fe9a42c7b9ca4a578ec8de4f7c566a392020-11-25T03:47:13ZengBMCBMC Chemistry2661-801X2020-08-011411810.1186/s13065-020-00701-6Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modificationBelete B. Beyene0Getaneh A. Wassie1Department of Chemistry, Bahir Dar UniversityDepartment of Chemistry, Bahir Dar UniversityAbstract In this study, we report antibacterial activity of metalloporphyrins; 5, 10, 15, 20-tetrakis (para-X phenyl)porphyrinato M (II) [where X = H, NH2 and COOMe for M = Cu and X = COOH and OMe for M = Co]. The activity study of the as-synthesized metalloporphyrins toward two Gram-positive (S. aureus and S. pyogenes) and two Gram-negative (E. coli and K. pneumoniae) bacteria showed a promising inhibitory activity. Among the complexes under study, the highest antibacterial activity is observed for 5, 10, 15, 20-tetrakis (p-carboxyphenyl)porphyrinato cobalt (II), with inhibition zone of 16.5 mm against Staphylococcus aureus (S. aureus). This activity could be attributed to the high binding ability of COOH group to cellular components, membranes, proteins, and DNA as well as the lipophilicity of the complex. Moreover, consistent with literature report, the study revealed that metalloporphyrins with electron withdrawing group at para-positions have better antibacterial activity than metalloporphyrin which possess electron donating group at para position.http://link.springer.com/article/10.1186/s13065-020-00701-6Cobalt porphyrinInhibitionCopper porphyrinAntibacterial activityLipophilicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Belete B. Beyene Getaneh A. Wassie |
spellingShingle |
Belete B. Beyene Getaneh A. Wassie Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification BMC Chemistry Cobalt porphyrin Inhibition Copper porphyrin Antibacterial activity Lipophilicity |
author_facet |
Belete B. Beyene Getaneh A. Wassie |
author_sort |
Belete B. Beyene |
title |
Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification |
title_short |
Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification |
title_full |
Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification |
title_fullStr |
Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification |
title_full_unstemmed |
Antibacterial activity of Cu(II) and Co(II) porphyrins: role of ligand modification |
title_sort |
antibacterial activity of cu(ii) and co(ii) porphyrins: role of ligand modification |
publisher |
BMC |
series |
BMC Chemistry |
issn |
2661-801X |
publishDate |
2020-08-01 |
description |
Abstract In this study, we report antibacterial activity of metalloporphyrins; 5, 10, 15, 20-tetrakis (para-X phenyl)porphyrinato M (II) [where X = H, NH2 and COOMe for M = Cu and X = COOH and OMe for M = Co]. The activity study of the as-synthesized metalloporphyrins toward two Gram-positive (S. aureus and S. pyogenes) and two Gram-negative (E. coli and K. pneumoniae) bacteria showed a promising inhibitory activity. Among the complexes under study, the highest antibacterial activity is observed for 5, 10, 15, 20-tetrakis (p-carboxyphenyl)porphyrinato cobalt (II), with inhibition zone of 16.5 mm against Staphylococcus aureus (S. aureus). This activity could be attributed to the high binding ability of COOH group to cellular components, membranes, proteins, and DNA as well as the lipophilicity of the complex. Moreover, consistent with literature report, the study revealed that metalloporphyrins with electron withdrawing group at para-positions have better antibacterial activity than metalloporphyrin which possess electron donating group at para position. |
topic |
Cobalt porphyrin Inhibition Copper porphyrin Antibacterial activity Lipophilicity |
url |
http://link.springer.com/article/10.1186/s13065-020-00701-6 |
work_keys_str_mv |
AT beletebbeyene antibacterialactivityofcuiiandcoiiporphyrinsroleofligandmodification AT getanehawassie antibacterialactivityofcuiiandcoiiporphyrinsroleofligandmodification |
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1724502849625260032 |