Dietary Factors of <i>bla</i><sub>NDM</sub> Carriage in Health Community Population: A Cross-Sectional Study
Aim: There is an ongoing debate as to what extent antimicrobial resistance (AMR) can be transmitted from dietary to humans via the consumption of food products. We investigated this association between dietary and global spreading carbapenem-resistant gene <i>bla</i><sub>NDM</su...
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doaj-fea21207bc6247549104cff998eaf44a2021-06-30T23:05:43ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012021-06-01185959595910.3390/ijerph18115959Dietary Factors of <i>bla</i><sub>NDM</sub> Carriage in Health Community Population: A Cross-Sectional StudyShuangfang Hu0Ziquan Lv1Qiumei Xiang2Yang Wang3Jianzhong Shen4Yuebin Ke5Key Laboratory of Molecular Epidemiology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, ChinaKey Laboratory of Molecular Epidemiology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, ChinaKey Laboratory of Molecular Epidemiology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing 100083, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing 100083, ChinaKey Laboratory of Molecular Epidemiology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, ChinaAim: There is an ongoing debate as to what extent antimicrobial resistance (AMR) can be transmitted from dietary to humans via the consumption of food products. We investigated this association between dietary and global spreading carbapenem-resistant gene <i>bla</i><sub>NDM</sub> Methods: We did a cross-sectional study to assess the risk factors for carrier of <i>bla</i><sub>NDM</sub> in health community. Healthy adults were recruited from the residents attending Community Healthcare Service in Shenzhen City (Guangdong Province, China), through 1February 2018 to 31December 2019, and 718 pre-participants were included in this study. Questionnaire were obtained and the qualitative food frequency questionnaire (Q-FFQ) were used to assess dietary intake. qPCR was applied to confirm the carrier of <i>bla</i><sub>NDM</sub> in participants’fecal samples. Multivariable logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (95% CI) of each outcome according to each dietary factor before and after prosperity score matching (PSM). Results: we showed that a high intake of coarse grain (OR 1.003; 95% CI 1.001–1.005, <i>p</i> < 0.01) and root and tuber crops (OR 1.003; 95% CI 1.001–1.004, <i>p</i> < 0.05) were independent risk factor for <i>bla</i><sub>NDM</sub> carrier in health communities, suggesting a possible transfer of AMRbetweendietary andhumans. Surprisingly, we also showed an association between a higher intake of poultry as a protective, which may be explained by the beneficial effects on the gut microbiota. Conclusion: Dietary factors such as intake of coarse grain, root and tuber crops and poultry were associated with <i>bla</i><sub>NDM</sub> carrier in health communities. The influence of dietary factorson <i>bla</i><sub>NDM</sub> carrier in the present study provides insights for the tangible dietary advice with guidelines to the routine of people with the risk of <i>bla</i><sub>NDM</sub> carrier. This demonstrates the role of dietary intake in the prevention of <i>bla</i><sub>NDM</sub> carrier, since prevention is the best way to control modifiable risk factors. A lower carrier rate of <i>bla</i><sub>NDM</sub> is helpful to reduce the possibility of transmission and pathogenicity. Further studies on food, microbiota and antimicrobial resistance are necessary to confirm this possible association and unravel underlying mechanisms.https://www.mdpi.com/1660-4601/18/11/5959<i>bla</i><sub>NDM</sub>epidemiologydietary factorrisk analysiscross-sectional study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shuangfang Hu Ziquan Lv Qiumei Xiang Yang Wang Jianzhong Shen Yuebin Ke |
spellingShingle |
Shuangfang Hu Ziquan Lv Qiumei Xiang Yang Wang Jianzhong Shen Yuebin Ke Dietary Factors of <i>bla</i><sub>NDM</sub> Carriage in Health Community Population: A Cross-Sectional Study International Journal of Environmental Research and Public Health <i>bla</i><sub>NDM</sub> epidemiology dietary factor risk analysis cross-sectional study |
author_facet |
Shuangfang Hu Ziquan Lv Qiumei Xiang Yang Wang Jianzhong Shen Yuebin Ke |
author_sort |
Shuangfang Hu |
title |
Dietary Factors of <i>bla</i><sub>NDM</sub> Carriage in Health Community Population: A Cross-Sectional Study |
title_short |
Dietary Factors of <i>bla</i><sub>NDM</sub> Carriage in Health Community Population: A Cross-Sectional Study |
title_full |
Dietary Factors of <i>bla</i><sub>NDM</sub> Carriage in Health Community Population: A Cross-Sectional Study |
title_fullStr |
Dietary Factors of <i>bla</i><sub>NDM</sub> Carriage in Health Community Population: A Cross-Sectional Study |
title_full_unstemmed |
Dietary Factors of <i>bla</i><sub>NDM</sub> Carriage in Health Community Population: A Cross-Sectional Study |
title_sort |
dietary factors of <i>bla</i><sub>ndm</sub> carriage in health community population: a cross-sectional study |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2021-06-01 |
description |
Aim: There is an ongoing debate as to what extent antimicrobial resistance (AMR) can be transmitted from dietary to humans via the consumption of food products. We investigated this association between dietary and global spreading carbapenem-resistant gene <i>bla</i><sub>NDM</sub> Methods: We did a cross-sectional study to assess the risk factors for carrier of <i>bla</i><sub>NDM</sub> in health community. Healthy adults were recruited from the residents attending Community Healthcare Service in Shenzhen City (Guangdong Province, China), through 1February 2018 to 31December 2019, and 718 pre-participants were included in this study. Questionnaire were obtained and the qualitative food frequency questionnaire (Q-FFQ) were used to assess dietary intake. qPCR was applied to confirm the carrier of <i>bla</i><sub>NDM</sub> in participants’fecal samples. Multivariable logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (95% CI) of each outcome according to each dietary factor before and after prosperity score matching (PSM). Results: we showed that a high intake of coarse grain (OR 1.003; 95% CI 1.001–1.005, <i>p</i> < 0.01) and root and tuber crops (OR 1.003; 95% CI 1.001–1.004, <i>p</i> < 0.05) were independent risk factor for <i>bla</i><sub>NDM</sub> carrier in health communities, suggesting a possible transfer of AMRbetweendietary andhumans. Surprisingly, we also showed an association between a higher intake of poultry as a protective, which may be explained by the beneficial effects on the gut microbiota. Conclusion: Dietary factors such as intake of coarse grain, root and tuber crops and poultry were associated with <i>bla</i><sub>NDM</sub> carrier in health communities. The influence of dietary factorson <i>bla</i><sub>NDM</sub> carrier in the present study provides insights for the tangible dietary advice with guidelines to the routine of people with the risk of <i>bla</i><sub>NDM</sub> carrier. This demonstrates the role of dietary intake in the prevention of <i>bla</i><sub>NDM</sub> carrier, since prevention is the best way to control modifiable risk factors. A lower carrier rate of <i>bla</i><sub>NDM</sub> is helpful to reduce the possibility of transmission and pathogenicity. Further studies on food, microbiota and antimicrobial resistance are necessary to confirm this possible association and unravel underlying mechanisms. |
topic |
<i>bla</i><sub>NDM</sub> epidemiology dietary factor risk analysis cross-sectional study |
url |
https://www.mdpi.com/1660-4601/18/11/5959 |
work_keys_str_mv |
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