Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo

Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32c to act as an effective cytoto...

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Bibliographic Details
Main Authors: Guangyao Lv, Dengjun Sun, Jingwen Zhang, Xiaoxia Xie, Xiaoqiong Wu, Weishuo Fang, Jingwei Tian, Chunhong Yan, Hongbo Wang, Fenghua Fu
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Lx2-32c
Cephalomannine
Prostate cancer
Microtubule
Cell cycle arrest
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516300715

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