A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature
Choriocarcinoma is the most malignant tumour of gestational trophoblastic origin. Most ovarian choriocarcinomas are gestational in origin and usually metastasize to the ovary from uterine or tubal choriocarcinoma. Non gestational choriocarcinoma (NGOC) of the ovary is exceedingly rare and usually se...
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doaj-feac01c3d0544da98230f15ee8c9a3f72021-04-02T12:39:27ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Neurosciences in Rural Practice0976-31470976-31552019-09-01060457858110.4103/0976-3147.169780A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literatureK.V.L Narasinga Rao0Subhas Konar1Jagathlal Gangadharan2V. Vikas3S. Sampath4Department of Neurosurgery, NIMHANS, Bengaluru, Karnataka, IndiaDepartment of Neurosurgery, NIMHANS, Bengaluru, Karnataka, IndiaDepartment of Neurosurgery, NIMHANS, Bengaluru, Karnataka, IndiaDepartment of Neurosurgery, NIMHANS, Bengaluru, Karnataka, IndiaDepartment of Neurosurgery, NIMHANS, Bengaluru, Karnataka, IndiaChoriocarcinoma is the most malignant tumour of gestational trophoblastic origin. Most ovarian choriocarcinomas are gestational in origin and usually metastasize to the ovary from uterine or tubal choriocarcinoma. Non gestational choriocarcinoma (NGOC) of the ovary is exceedingly rare and usually seen along with other germ cell tumors. Non gestational choriocarcinoma has been found to be resistant to single-agent chemotherapy and has a worse prognosis than gestational choriocarcinoma. We are reporting long term follow up of published rare case of pure non gestational ovarian choriocarcinoma (NGOC) with concurrent metastases to the spleen and adrenal glands, who developed a delayed solitary brain metastases, two years after completion of primary treatment. Surgery along with triple agent chemotherapy and radiotherapy was found to give good remission in this aggressive disease.http://www.thieme-connect.de/DOI/DOI?10.4103/0976-3147.169780Delayed metastaseshuman chorionic gonadotropinovarian non-gestational choriocarcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
K.V.L Narasinga Rao Subhas Konar Jagathlal Gangadharan V. Vikas S. Sampath |
spellingShingle |
K.V.L Narasinga Rao Subhas Konar Jagathlal Gangadharan V. Vikas S. Sampath A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature Journal of Neurosciences in Rural Practice Delayed metastases human chorionic gonadotropin ovarian non-gestational choriocarcinoma |
author_facet |
K.V.L Narasinga Rao Subhas Konar Jagathlal Gangadharan V. Vikas S. Sampath |
author_sort |
K.V.L Narasinga Rao |
title |
A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature |
title_short |
A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature |
title_full |
A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature |
title_fullStr |
A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature |
title_full_unstemmed |
A pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: Case report and review of the literature |
title_sort |
pure non-gestational ovarian choriocarcinoma with delayed solitary brain metastases: case report and review of the literature |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
Journal of Neurosciences in Rural Practice |
issn |
0976-3147 0976-3155 |
publishDate |
2019-09-01 |
description |
Choriocarcinoma is the most malignant tumour of gestational trophoblastic origin. Most ovarian choriocarcinomas are gestational in origin and usually metastasize to the ovary from uterine or tubal choriocarcinoma. Non gestational choriocarcinoma (NGOC) of the ovary is exceedingly rare and usually seen along with other germ cell tumors. Non gestational choriocarcinoma has been found to be resistant to single-agent chemotherapy and has a worse prognosis than gestational choriocarcinoma. We are reporting long term follow up of published rare case of pure non gestational ovarian choriocarcinoma (NGOC) with concurrent metastases to the spleen and adrenal glands, who developed a delayed solitary brain metastases, two years after completion of primary treatment. Surgery along with triple agent chemotherapy and radiotherapy was found to give good remission in this aggressive disease. |
topic |
Delayed metastases human chorionic gonadotropin ovarian non-gestational choriocarcinoma |
url |
http://www.thieme-connect.de/DOI/DOI?10.4103/0976-3147.169780 |
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