Glucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile function.
We recently demonstrated that a 17-ketosteroid, epiandrosterone, attenuates L-type Ca(2+) currents (I(Ca-L)) in cardiac myocytes and inhibits myocardial contractility. Because 17-ketosteroids are known to inhibit glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosp...
Main Authors: | Dhwajbahadur K Rawat, Peter Hecker, Makino Watanabe, Sukrutha Chettimada, Richard J Levy, Takao Okada, John G Edwards, Sachin A Gupte |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3465299?pdf=render |
Similar Items
-
Poly(ethylene glycol)-cholesterol inhibits L-type Ca2+ channel currents and augments voltage-dependent inactivation in A7r5 cells.
by: Rikuo Ochi, et al.
Published: (2014-01-01) -
Effects of Cellular Glucose-6-phosphate Dehydrogenase on NADPH, NADPH-Generating Enzymes and NADPH-Dependent Enzymes in HepG2 Cells
by: Yu Hsiu Yang, et al.
Published: (2008) -
Effect of nitric oxide donors on myocyte contractile function
by: Sarkar, David Anthony
Published: (2003) -
Cardiac failure and overload : contractile changes in single myocytes
by: Monte, Frederica del
Published: (1996) -
The Role of Glyceraldehyde-3-Phosphate Dehydrogenases in NADPH Supply in the Oleaginous Filamentous Fungus Mortierella alpina
by: Shunxian Wang, et al.
Published: (2020-04-01)