Frequency-selective control of cortical and subcortical networks by central thalamus

Central thalamus plays a critical role in forebrain arousal and organized behavior. However, network-level mechanisms that link its activity to brain state remain enigmatic. Here, we combined optogenetics, fMRI, electrophysiology, and video-EEG monitoring to characterize the central thalamus-driven...

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Main Authors:	Jia Liu, Hyun Joo Lee, Andrew J Weitz, Zhongnan Fang, Peter Lin, ManKin Choy, Robert Fisher, Vadim Pinskiy, Alexander Tolpygo, Partha Mitra, Nicholas Schiff, Jin Hyung Lee
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-12-01
Series:	eLife
Subjects:	Central thalamus Functional MRI Optogenetics Arousal
Online Access:	https://elifesciences.org/articles/09215

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spelling	doaj-feb5874de8c94ec5ab879c3a387fe5052021-05-05T00:09:26ZengeLife Sciences Publications LtdeLife2050-084X2015-12-01410.7554/eLife.09215Frequency-selective control of cortical and subcortical networks by central thalamusJia Liu0Hyun Joo Lee1Andrew J Weitz2Zhongnan Fang3Peter Lin4ManKin Choy5Robert Fisher6Vadim Pinskiy7Alexander Tolpygo8Partha Mitra9Nicholas Schiff10Jin Hyung Lee11Department of Neurology and Neurological Sciences, Stanford University, Stanford, United StatesDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, United StatesDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, United States; Department of Bioengineering, Stanford University, Stanford, United StatesDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, United States; Department of Electrical Engineering, Stanford University, Stanford, United StatesDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, United StatesDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, United StatesDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, United StatesCold Spring Harbor Laboratory, Cold Spring Harbor, United StatesCold Spring Harbor Laboratory, Cold Spring Harbor, United StatesCold Spring Harbor Laboratory, Cold Spring Harbor, United StatesDepartment of Neurology, Weill Cornell Medical College, New York, United StatesDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, United States; Department of Bioengineering, Stanford University, Stanford, United States; Department of Electrical Engineering, Stanford University, Stanford, United States; Department of Neurosurgery, Stanford University, Stanford, United StatesCentral thalamus plays a critical role in forebrain arousal and organized behavior. However, network-level mechanisms that link its activity to brain state remain enigmatic. Here, we combined optogenetics, fMRI, electrophysiology, and video-EEG monitoring to characterize the central thalamus-driven global brain networks responsible for switching brain state. 40 and 100 Hz stimulations of central thalamus caused widespread activation of forebrain, including frontal cortex, sensorimotor cortex, and striatum, and transitioned the brain to a state of arousal in asleep rats. In contrast, 10 Hz stimulation evoked significantly less activation of forebrain, inhibition of sensory cortex, and behavioral arrest. To investigate possible mechanisms underlying the frequency-dependent cortical inhibition, we performed recordings in zona incerta, where 10, but not 40, Hz stimulation evoked spindle-like oscillations. Importantly, suppressing incertal activity during 10 Hz central thalamus stimulation reduced the evoked cortical inhibition. These findings identify key brain-wide dynamics underlying central thalamus arousal regulation.https://elifesciences.org/articles/09215Central thalamusFunctional MRIOptogeneticsArousal
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jia Liu Hyun Joo Lee Andrew J Weitz Zhongnan Fang Peter Lin ManKin Choy Robert Fisher Vadim Pinskiy Alexander Tolpygo Partha Mitra Nicholas Schiff Jin Hyung Lee
spellingShingle	Jia Liu Hyun Joo Lee Andrew J Weitz Zhongnan Fang Peter Lin ManKin Choy Robert Fisher Vadim Pinskiy Alexander Tolpygo Partha Mitra Nicholas Schiff Jin Hyung Lee Frequency-selective control of cortical and subcortical networks by central thalamus eLife Central thalamus Functional MRI Optogenetics Arousal
author_facet	Jia Liu Hyun Joo Lee Andrew J Weitz Zhongnan Fang Peter Lin ManKin Choy Robert Fisher Vadim Pinskiy Alexander Tolpygo Partha Mitra Nicholas Schiff Jin Hyung Lee
author_sort	Jia Liu
title	Frequency-selective control of cortical and subcortical networks by central thalamus
title_short	Frequency-selective control of cortical and subcortical networks by central thalamus
title_full	Frequency-selective control of cortical and subcortical networks by central thalamus
title_fullStr	Frequency-selective control of cortical and subcortical networks by central thalamus
title_full_unstemmed	Frequency-selective control of cortical and subcortical networks by central thalamus
title_sort	frequency-selective control of cortical and subcortical networks by central thalamus
publisher	eLife Sciences Publications Ltd
series	eLife
issn	2050-084X
publishDate	2015-12-01
description	Central thalamus plays a critical role in forebrain arousal and organized behavior. However, network-level mechanisms that link its activity to brain state remain enigmatic. Here, we combined optogenetics, fMRI, electrophysiology, and video-EEG monitoring to characterize the central thalamus-driven global brain networks responsible for switching brain state. 40 and 100 Hz stimulations of central thalamus caused widespread activation of forebrain, including frontal cortex, sensorimotor cortex, and striatum, and transitioned the brain to a state of arousal in asleep rats. In contrast, 10 Hz stimulation evoked significantly less activation of forebrain, inhibition of sensory cortex, and behavioral arrest. To investigate possible mechanisms underlying the frequency-dependent cortical inhibition, we performed recordings in zona incerta, where 10, but not 40, Hz stimulation evoked spindle-like oscillations. Importantly, suppressing incertal activity during 10 Hz central thalamus stimulation reduced the evoked cortical inhibition. These findings identify key brain-wide dynamics underlying central thalamus arousal regulation.
topic	Central thalamus Functional MRI Optogenetics Arousal
url	https://elifesciences.org/articles/09215
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Frequency-selective control of cortical and subcortical networks by central thalamus

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