IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis
Background. IGF-I and IGFBP-3 are part of IGF system and, due to their predominantly hepatic synthesis, they seem to correlate with hepatic dysfunction intensity. Aims. To investigate the significance of IGF-I and IGFBP-3 in patients with decompensated liver disease.Material and methods. Cross-secti...
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doaj-feb5b9ce51694bc187d2e468f1d772932021-06-09T05:53:05ZengElsevierAnnals of Hepatology1665-26812013-05-01123456463IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosisMarcelo Fernando Ronsoni0Cesar Lazzarotto1Leonardo Fayad2Mariana Costa Silva3Christiane Lourenço Nogueira4Maria Luiza Bazzo5Janaína Luz Narciso-Schiavon6Esther Buzaglo Dantas-Corrêa7Leonardo de Lucca Schiavon8Division of Gastroenterology, Federal University of Santa Catarina, BrazilDivision of Gastroenterology, Federal University of Santa Catarina, BrazilDivision of Gastroenterology, Federal University of Santa Catarina, BrazilDivision of Gastroenterology, Federal University of Santa Catarina, BrazilDepartment of Clinical Analysis, Federal University of Santa Catarina, BrazilDepartment of Clinical Analysis, Federal University of Santa Catarina, BrazilDivision of Gastroenterology, Federal University of Santa Catarina, BrazilDivision of Gastroenterology, Federal University of Santa Catarina, BrazilDivision of Gastroenterology, Federal University of Santa Catarina, Brazil; Correspondence and reprint request:Background. IGF-I and IGFBP-3 are part of IGF system and, due to their predominantly hepatic synthesis, they seem to correlate with hepatic dysfunction intensity. Aims. To investigate the significance of IGF-I and IGFBP-3 in patients with decompensated liver disease.Material and methods. Cross-sectional study that included cirrhotic patients admitted to hospital due to complications of the disease, in whom IGF-I and IGFBP-3 serum levels were measured by chemiluminescence. Results. Seventy-four subjects with a mean age of 53.1 ± 11.6 years were included in the study, 73% were males. IGF-I levels were positively correlated with IGFBP-3 and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR and aPTT ratio. IGFBP-3 levels were positively correlated with IGF-I and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR, total bilirubin and aPTT ratio. Significantly lower scores of IGF-I and IGFBP-3 were observed in patients with higher MELD values and higher Child-Pugh classes (P < 0.05).Conclusions. In cirrhotic patients admitted to hospital due to complications of the disease, IGF-I and IGFBP-3 serum levels were associated with variables related to liver dysfunction and to more advanced liver disease. The levels of these markers seem to undergo little influence from other clinical and laboratory variables, therefore mainly reflecting hepatic functional status.http://www.sciencedirect.com/science/article/pii/S1665268119310099Insulin-like growth factor IInsulin-like growth factor-binding protein-3Complications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcelo Fernando Ronsoni Cesar Lazzarotto Leonardo Fayad Mariana Costa Silva Christiane Lourenço Nogueira Maria Luiza Bazzo Janaína Luz Narciso-Schiavon Esther Buzaglo Dantas-Corrêa Leonardo de Lucca Schiavon |
spellingShingle |
Marcelo Fernando Ronsoni Cesar Lazzarotto Leonardo Fayad Mariana Costa Silva Christiane Lourenço Nogueira Maria Luiza Bazzo Janaína Luz Narciso-Schiavon Esther Buzaglo Dantas-Corrêa Leonardo de Lucca Schiavon IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis Annals of Hepatology Insulin-like growth factor I Insulin-like growth factor-binding protein-3 Complications |
author_facet |
Marcelo Fernando Ronsoni Cesar Lazzarotto Leonardo Fayad Mariana Costa Silva Christiane Lourenço Nogueira Maria Luiza Bazzo Janaína Luz Narciso-Schiavon Esther Buzaglo Dantas-Corrêa Leonardo de Lucca Schiavon |
author_sort |
Marcelo Fernando Ronsoni |
title |
IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis |
title_short |
IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis |
title_full |
IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis |
title_fullStr |
IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis |
title_full_unstemmed |
IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis |
title_sort |
igf-i and igfbp-3 serum levels in patients hospitalized for complications of liver cirrhosis |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2013-05-01 |
description |
Background. IGF-I and IGFBP-3 are part of IGF system and, due to their predominantly hepatic synthesis, they seem to correlate with hepatic dysfunction intensity. Aims. To investigate the significance of IGF-I and IGFBP-3 in patients with decompensated liver disease.Material and methods. Cross-sectional study that included cirrhotic patients admitted to hospital due to complications of the disease, in whom IGF-I and IGFBP-3 serum levels were measured by chemiluminescence. Results. Seventy-four subjects with a mean age of 53.1 ± 11.6 years were included in the study, 73% were males. IGF-I levels were positively correlated with IGFBP-3 and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR and aPTT ratio. IGFBP-3 levels were positively correlated with IGF-I and albumin, and negatively correlated with Child-Pugh, MELD, creatinine, INR, total bilirubin and aPTT ratio. Significantly lower scores of IGF-I and IGFBP-3 were observed in patients with higher MELD values and higher Child-Pugh classes (P < 0.05).Conclusions. In cirrhotic patients admitted to hospital due to complications of the disease, IGF-I and IGFBP-3 serum levels were associated with variables related to liver dysfunction and to more advanced liver disease. The levels of these markers seem to undergo little influence from other clinical and laboratory variables, therefore mainly reflecting hepatic functional status. |
topic |
Insulin-like growth factor I Insulin-like growth factor-binding protein-3 Complications |
url |
http://www.sciencedirect.com/science/article/pii/S1665268119310099 |
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