Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference
Other than clean drinking water, vaccines have been the most effective public health intervention in human history, yet their full potential is still untapped. To date, vaccine development has been largely limited to empirical approaches focused on infectious diseases and has targeted entire populat...
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doaj-febfe2deb9934131aa7a5e46c845c0ea2020-11-25T03:07:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.590373590373Towards Precision Vaccines: Lessons From the Second International Precision Vaccines ConferenceDheeraj Soni0Dheeraj Soni1Simon D. Van Haren2Simon D. Van Haren3Olubukola T. Idoko4Olubukola T. Idoko5Jay T. Evans6Joann Diray-Arce7Joann Diray-Arce8Joann Diray-Arce9David J. Dowling10David J. Dowling11Ofer Levy12Ofer Levy13Ofer Levy14Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Pediatrics, Harvard Medical School, Boston, MA, United StatesPrecision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Pediatrics, Harvard Medical School, Boston, MA, United StatesPrecision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United StatesVaccine Centre, London School of Hygiene and Tropical Medicine, London, United KingdomCenter for Translational Medicine, University of Montana, Missoula, MT, United StatesPrecision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Pediatrics, Harvard Medical School, Boston, MA, United StatesBroad Institute of MIT & Harvard, Cambridge, MA, United StatesPrecision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Pediatrics, Harvard Medical School, Boston, MA, United StatesPrecision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Pediatrics, Harvard Medical School, Boston, MA, United StatesBroad Institute of MIT & Harvard, Cambridge, MA, United StatesOther than clean drinking water, vaccines have been the most effective public health intervention in human history, yet their full potential is still untapped. To date, vaccine development has been largely limited to empirical approaches focused on infectious diseases and has targeted entire populations, potentially disregarding distinct immunity in vulnerable populations such as infants, elders, and the immunocompromised. Over the past few decades innovations in genetic engineering, adjuvant discovery, formulation science, and systems biology have fueled rapid advances in vaccine research poised to consider demographic factors (e.g., age, sex, genetics, and epigenetics) in vaccine discovery and development. Current efforts are focused on leveraging novel approaches to vaccine discovery and development to optimize vaccinal antigen and, as needed, adjuvant systems to enhance vaccine immunogenicity while maintaining safety. These approaches are ushering in an era of precision vaccinology aimed at tailoring immunization for vulnerable populations with distinct immunity. To foster collaboration among leading vaccinologists, government, policy makers, industry partners, and funders from around the world, the Precision Vaccines Program at Boston Children’s Hospital hosted the 2nd International Precision Vaccines Conference (IPVC) at Harvard Medical School on the 17th–18th October 2019. The conference convened experts in vaccinology, including vaccine formulation and adjuvantation, immunology, cell signaling, systems biology, biostatistics, bioinformatics, as well as vaccines for non-infectious indications such as cancer and opioid use disorder. Herein we review highlights from the 2nd IPVC and discuss key concepts in the field of precision vaccines.https://www.frontiersin.org/article/10.3389/fimmu.2020.590373/fullprecision vaccinessystems biologyInternational Precision Vaccines Conferencevaccinologistsnon-infectious diseasesadjuvants |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dheeraj Soni Dheeraj Soni Simon D. Van Haren Simon D. Van Haren Olubukola T. Idoko Olubukola T. Idoko Jay T. Evans Joann Diray-Arce Joann Diray-Arce Joann Diray-Arce David J. Dowling David J. Dowling Ofer Levy Ofer Levy Ofer Levy |
spellingShingle |
Dheeraj Soni Dheeraj Soni Simon D. Van Haren Simon D. Van Haren Olubukola T. Idoko Olubukola T. Idoko Jay T. Evans Joann Diray-Arce Joann Diray-Arce Joann Diray-Arce David J. Dowling David J. Dowling Ofer Levy Ofer Levy Ofer Levy Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference Frontiers in Immunology precision vaccines systems biology International Precision Vaccines Conference vaccinologists non-infectious diseases adjuvants |
author_facet |
Dheeraj Soni Dheeraj Soni Simon D. Van Haren Simon D. Van Haren Olubukola T. Idoko Olubukola T. Idoko Jay T. Evans Joann Diray-Arce Joann Diray-Arce Joann Diray-Arce David J. Dowling David J. Dowling Ofer Levy Ofer Levy Ofer Levy |
author_sort |
Dheeraj Soni |
title |
Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference |
title_short |
Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference |
title_full |
Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference |
title_fullStr |
Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference |
title_full_unstemmed |
Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference |
title_sort |
towards precision vaccines: lessons from the second international precision vaccines conference |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2020-10-01 |
description |
Other than clean drinking water, vaccines have been the most effective public health intervention in human history, yet their full potential is still untapped. To date, vaccine development has been largely limited to empirical approaches focused on infectious diseases and has targeted entire populations, potentially disregarding distinct immunity in vulnerable populations such as infants, elders, and the immunocompromised. Over the past few decades innovations in genetic engineering, adjuvant discovery, formulation science, and systems biology have fueled rapid advances in vaccine research poised to consider demographic factors (e.g., age, sex, genetics, and epigenetics) in vaccine discovery and development. Current efforts are focused on leveraging novel approaches to vaccine discovery and development to optimize vaccinal antigen and, as needed, adjuvant systems to enhance vaccine immunogenicity while maintaining safety. These approaches are ushering in an era of precision vaccinology aimed at tailoring immunization for vulnerable populations with distinct immunity. To foster collaboration among leading vaccinologists, government, policy makers, industry partners, and funders from around the world, the Precision Vaccines Program at Boston Children’s Hospital hosted the 2nd International Precision Vaccines Conference (IPVC) at Harvard Medical School on the 17th–18th October 2019. The conference convened experts in vaccinology, including vaccine formulation and adjuvantation, immunology, cell signaling, systems biology, biostatistics, bioinformatics, as well as vaccines for non-infectious indications such as cancer and opioid use disorder. Herein we review highlights from the 2nd IPVC and discuss key concepts in the field of precision vaccines. |
topic |
precision vaccines systems biology International Precision Vaccines Conference vaccinologists non-infectious diseases adjuvants |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.590373/full |
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