Micro-PET Imaging Demonstrates 3-O-β-D-Glucopyranosyl Platycodigenin as an Effective Metabolite Affects Permeability of Cell Membrane and Improves Dosimetry of [18F]-Phillygenin in Lung Tissue

Micro-PET Imaging Demonstrates 3-O-β-D-Glucopyranosyl Platycodigenin as an Effective Metabolite Affects Permeability of Cell Membrane and Improves Dosimetry of [18F]-Phillygenin in Lung Tissue

Platycodon grandiflorum, as a traditional medicinal plant, is commonly used in the treatment of pulmonary disease. Platycodon saponins are proposed as active ingredients. However, the role of secondary saponin metabolites (SSM) in the traditional use of Platycodon has not yet been fully clarified. I...

Full description

Bibliographic Details
Main Authors: Fukui Shen, Wenbo Wu, Man Zhang, Xiaoyao Ma, Qingxin Cui, Zhongyao Tang, Hao Huang, Tiantian Tong, Leefong Yau, Zhihong Jiang, Yuanyuan Hou, Gang Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
Platycodon grandiflorum
secondary saponin
3-O-β-D-glucopyranosyl platycodigenin
[18F]-phillygenin
micro-positron emission tomography
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01020/full

Similar Items

Similar Items