Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis
Cardiovascular diseases are the leading cause of death worldwide in different cohorts. It is well known that miRNAs have a crucial role in regulating the development of cardiovascular physiology, thus impacting the pathophysiology of heart diseases. MiRNAs also have been reported to be associated wi...
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doaj-fec80489a8a34be0819602f670be4a0c2021-02-20T00:03:33ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-02-018222210.3390/jcdd8020022Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and AtherosclerosisRashid Mir0Imadeldin Elfaki1Naina Khullar2Ajaz Ahmad Waza3Chandan Jha4Mohammad Muzaffar Mir5Shamsu Nisa6Babar Mohammad7Tahir Ahmad Mir8Mohsin Maqbool9Jameel Barnawi10Salem Owaid Albalawi11Faisel M. Abu-Duhier12Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Zoology, Mata Gujri College, Fatehgarh Sahib, Punjab 140406, IndiaDepartment of Microbiology, Government Medical College (GMC), Kashmir, J & K, Srinagar 190010, IndiaDepartment of Human Genetics, Punjabi University, Punjab, Chandigarh 147002, IndiaDepartment of Basic Medical Sciences (Biochemistry) College of Medicine, University of Bisha, Bisha 61922, Saudi ArabiaDepartment of Obstetrics & Gynaecology, Sher-i-Kashmir Institute of Medical Sciences, J &K, Srinagar, Soura 190011, IndiaDepartment of Radiodiagnosis and Imaging, Government Medical College (GMC), Kashmir, J & K, Srinagar 190010, IndiaInderprastha Dental College & Hospital, Ghaziabad, Uttar Pradesh, New Delhi 201010, IndiaDana Farber Cancer Institute, Boston, MA 02215, USADepartment of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Cardiology, King Fahd Special Hospital, Tabuk 71491, Saudi ArabiaDepartment of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi ArabiaCardiovascular diseases are the leading cause of death worldwide in different cohorts. It is well known that miRNAs have a crucial role in regulating the development of cardiovascular physiology, thus impacting the pathophysiology of heart diseases. MiRNAs also have been reported to be associated with cardiac reactions, leading to myocardial infarction (MCI) and ultimately heart failure (HF). To prevent these heart diseases, proper and timely diagnosis of cardiac dysfunction is pivotal. Though there are many symptoms associated with an irregular heart condition and though there are some biomarkers available that may indicate heart disease, authentic, specific and sensitive markers are the need of the hour. In recent times, miRNAs have proven to be promising candidates in this regard. They are potent biomarkers as they can be easily detected in body fluids (blood, urine, etc.) due to their remarkable stability and presence in apoptotic bodies and exosomes. Existing studies suggest the role of miRNAs as valuable biomarkers. A single biomarker may be insufficient to diagnose coronary artery disease (CAD) or acute myocardial infarction (AMI); thus, a combination of different miRNAs may prove fruitful. Therefore, this review aims to highlight the role of circulating miRNA as diagnostic and prognostic biomarkers in cardiovascular diseases such as coronary artery disease (CAD), myocardial infarction (MI) and atherosclerosis.https://www.mdpi.com/2308-3425/8/2/22coronary artery diseaseCADcardiovascular diseasesmyocardial infarctionMIacute myocardial infarction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rashid Mir Imadeldin Elfaki Naina Khullar Ajaz Ahmad Waza Chandan Jha Mohammad Muzaffar Mir Shamsu Nisa Babar Mohammad Tahir Ahmad Mir Mohsin Maqbool Jameel Barnawi Salem Owaid Albalawi Faisel M. Abu-Duhier |
spellingShingle |
Rashid Mir Imadeldin Elfaki Naina Khullar Ajaz Ahmad Waza Chandan Jha Mohammad Muzaffar Mir Shamsu Nisa Babar Mohammad Tahir Ahmad Mir Mohsin Maqbool Jameel Barnawi Salem Owaid Albalawi Faisel M. Abu-Duhier Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis Journal of Cardiovascular Development and Disease coronary artery disease CAD cardiovascular diseases myocardial infarction MI acute myocardial infarction |
author_facet |
Rashid Mir Imadeldin Elfaki Naina Khullar Ajaz Ahmad Waza Chandan Jha Mohammad Muzaffar Mir Shamsu Nisa Babar Mohammad Tahir Ahmad Mir Mohsin Maqbool Jameel Barnawi Salem Owaid Albalawi Faisel M. Abu-Duhier |
author_sort |
Rashid Mir |
title |
Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis |
title_short |
Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis |
title_full |
Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis |
title_fullStr |
Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis |
title_full_unstemmed |
Role of Selected miRNAs as Diagnostic and Prognostic Biomarkers in Cardiovascular Diseases, Including Coronary Artery Disease, Myocardial Infarction and Atherosclerosis |
title_sort |
role of selected mirnas as diagnostic and prognostic biomarkers in cardiovascular diseases, including coronary artery disease, myocardial infarction and atherosclerosis |
publisher |
MDPI AG |
series |
Journal of Cardiovascular Development and Disease |
issn |
2308-3425 |
publishDate |
2021-02-01 |
description |
Cardiovascular diseases are the leading cause of death worldwide in different cohorts. It is well known that miRNAs have a crucial role in regulating the development of cardiovascular physiology, thus impacting the pathophysiology of heart diseases. MiRNAs also have been reported to be associated with cardiac reactions, leading to myocardial infarction (MCI) and ultimately heart failure (HF). To prevent these heart diseases, proper and timely diagnosis of cardiac dysfunction is pivotal. Though there are many symptoms associated with an irregular heart condition and though there are some biomarkers available that may indicate heart disease, authentic, specific and sensitive markers are the need of the hour. In recent times, miRNAs have proven to be promising candidates in this regard. They are potent biomarkers as they can be easily detected in body fluids (blood, urine, etc.) due to their remarkable stability and presence in apoptotic bodies and exosomes. Existing studies suggest the role of miRNAs as valuable biomarkers. A single biomarker may be insufficient to diagnose coronary artery disease (CAD) or acute myocardial infarction (AMI); thus, a combination of different miRNAs may prove fruitful. Therefore, this review aims to highlight the role of circulating miRNA as diagnostic and prognostic biomarkers in cardiovascular diseases such as coronary artery disease (CAD), myocardial infarction (MI) and atherosclerosis. |
topic |
coronary artery disease CAD cardiovascular diseases myocardial infarction MI acute myocardial infarction |
url |
https://www.mdpi.com/2308-3425/8/2/22 |
work_keys_str_mv |
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