Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia

Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia

Hypercalcemia is a common metabolic abnormality in children and generally occurs due to hyperparathyroidism, vitamin D toxicity, some genetic disorders and malignant diseases. Granulomatous diseases are a rare cause of hypercalcemia in children, which are usually mild and asymptomatic. Severe hyperc...

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Main Authors: Suna Kılınç, Özlem Bostan Gayret, Meltem Erol, Saide Ertürk, Tugce Damla Dilek, Özgül Yiğit
Format: Article
Language:English
Published: KARE Publishing 2020-08-01
Series:İstanbul Kuzey Klinikleri
Subjects:
bisphosphonates
hypercalcemia; miliary tuberculosis; pamidronate-disodium.
Online Access:https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-14890
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spelling doaj-fed72a724450421b94fd9fcebbb7e2522021-01-24T18:41:03ZengKARE Publishingİstanbul Kuzey Klinikleri2148-49022020-08-017441141410.14744/nci.2019.14890NCI-14890Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemiaSuna Kılınç0Özlem Bostan Gayret1Meltem Erol2Saide Ertürk3Tugce Damla Dilek4Özgül Yiğit5Department of PediatriDepartment of Pediatric Endocrinology, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkeyc Endocrinology, Istanbul Bağcılar Education and Research Hospital, Istanbul, TurkeyDepartment of Pediatrics, Istanbul Bagcilar Training and Research Hospital, Istanbul, TurkeyDepartment of Pediatrics, Istanbul Bagcilar Training and Research Hospital, Istanbul, TurkeyDepartment of Pediatrics, Istanbul Esenler Obstetrics and Pediatrics Hospital, Istanbul, TurkeyDepartment of Pediatrics, Istanbul Bagcilar Training and Research Hospital, Istanbul, TurkeyDepartment of Pediatrics, Istanbul Bagcilar Training and Research Hospital, Istanbul, TurkeyHypercalcemia is a common metabolic abnormality in children and generally occurs due to hyperparathyroidism, vitamin D toxicity, some genetic disorders and malignant diseases. Granulomatous diseases are a rare cause of hypercalcemia in children, which are usually mild and asymptomatic. Severe hypercalcemia in granulomatous diseases has also been reported in the literature. Here, we report a child presenting with severe hypercalcemia secondary to miliary tuberculosis with successful management with bisphosphonate treatment. Increased 1,25(OH)2D3 synthesis by activated macrophages in the granuloma tissue is the major mechanism of hypercalcemia in tuberculosis.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-14890bisphosphonateshypercalcemia; miliary tuberculosis; pamidronate-disodium.
collection DOAJ
language English
format Article
sources DOAJ
author Suna Kılınç
Özlem Bostan Gayret
Meltem Erol
Saide Ertürk
Tugce Damla Dilek
Özgül Yiğit
spellingShingle Suna Kılınç
Özlem Bostan Gayret
Meltem Erol
Saide Ertürk
Tugce Damla Dilek
Özgül Yiğit
Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia
İstanbul Kuzey Klinikleri
bisphosphonates
hypercalcemia; miliary tuberculosis; pamidronate-disodium.
author_facet Suna Kılınç
Özlem Bostan Gayret
Meltem Erol
Saide Ertürk
Tugce Damla Dilek
Özgül Yiğit
author_sort Suna Kılınç
title Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia
title_short Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia
title_full Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia
title_fullStr Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia
title_full_unstemmed Successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia
title_sort successful management with bisphosphonate treatment in a child with tuberculosis-associated hypercalcemia
publisher KARE Publishing
series İstanbul Kuzey Klinikleri
issn 2148-4902
publishDate 2020-08-01
description Hypercalcemia is a common metabolic abnormality in children and generally occurs due to hyperparathyroidism, vitamin D toxicity, some genetic disorders and malignant diseases. Granulomatous diseases are a rare cause of hypercalcemia in children, which are usually mild and asymptomatic. Severe hypercalcemia in granulomatous diseases has also been reported in the literature. Here, we report a child presenting with severe hypercalcemia secondary to miliary tuberculosis with successful management with bisphosphonate treatment. Increased 1,25(OH)2D3 synthesis by activated macrophages in the granuloma tissue is the major mechanism of hypercalcemia in tuberculosis.
topic bisphosphonates
hypercalcemia; miliary tuberculosis; pamidronate-disodium.
url https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-14890
work_keys_str_mv AT sunakılınc successfulmanagementwithbisphosphonatetreatmentinachildwithtuberculosisassociatedhypercalcemia
AT ozlembostangayret successfulmanagementwithbisphosphonatetreatmentinachildwithtuberculosisassociatedhypercalcemia
AT meltemerol successfulmanagementwithbisphosphonatetreatmentinachildwithtuberculosisassociatedhypercalcemia
AT saideerturk successfulmanagementwithbisphosphonatetreatmentinachildwithtuberculosisassociatedhypercalcemia
AT tugcedamladilek successfulmanagementwithbisphosphonatetreatmentinachildwithtuberculosisassociatedhypercalcemia
AT ozgulyigit successfulmanagementwithbisphosphonatetreatmentinachildwithtuberculosisassociatedhypercalcemia
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