Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer
Cancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate they are regulatory elements of known cancer genes.
Bibliographic Details
| Main Authors: |
Matteo D′Antonio,
Donate Weghorn,
Agnieszka D′Antonio-Chronowska,
Florence Coulet,
Katrina M. Olson,
Christopher DeBoever,
Frauke Drees,
Angelo Arias,
Hakan Alakus,
Andrea L. Richardson,
Richard B. Schwab,
Emma K. Farley,
Shamil R. Sunyaev,
Kelly A Frazer |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-00100-x
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