Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer
Cancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate they are regulatory elements of known cancer genes.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00100-x |
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doaj-fed8c71471284e789fe9fe3936d957c52021-05-11T07:07:52ZengNature Publishing GroupNature Communications2041-17232017-09-018111610.1038/s41467-017-00100-xIdentifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancerMatteo D′Antonio0Donate Weghorn1Agnieszka D′Antonio-Chronowska2Florence Coulet3Katrina M. Olson4Christopher DeBoever5Frauke Drees6Angelo Arias7Hakan Alakus8Andrea L. Richardson9Richard B. Schwab10Emma K. Farley11Shamil R. Sunyaev12Kelly A Frazer13Moores Cancer Center, University of CaliforniaDivision of Genetics, Brigham and Women’s Hospital, Harvard Medical SchoolInstitute for Genomic Medicine, University of CaliforniaDepartment of Pediatrics, University of CaliforniaDepartment of Medicine, Division of Cardiology, University of CaliforniaBioinformatics and Systems Biology, University of CaliforniaDepartment of Pediatrics, University of CaliforniaDepartment of Pediatrics, University of CaliforniaDepartment of Pediatrics, University of CaliforniaDepartment of Pathology, Brigham and Women’s Hospital and Harvard Medical SchoolMoores Cancer Center, University of CaliforniaDepartment of Medicine, Division of Cardiology, University of CaliforniaDivision of Genetics, Brigham and Women’s Hospital, Harvard Medical SchoolMoores Cancer Center, University of CaliforniaCancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate they are regulatory elements of known cancer genes.https://doi.org/10.1038/s41467-017-00100-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Matteo D′Antonio Donate Weghorn Agnieszka D′Antonio-Chronowska Florence Coulet Katrina M. Olson Christopher DeBoever Frauke Drees Angelo Arias Hakan Alakus Andrea L. Richardson Richard B. Schwab Emma K. Farley Shamil R. Sunyaev Kelly A Frazer |
| spellingShingle |
Matteo D′Antonio Donate Weghorn Agnieszka D′Antonio-Chronowska Florence Coulet Katrina M. Olson Christopher DeBoever Frauke Drees Angelo Arias Hakan Alakus Andrea L. Richardson Richard B. Schwab Emma K. Farley Shamil R. Sunyaev Kelly A Frazer Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer Nature Communications |
| author_facet |
Matteo D′Antonio Donate Weghorn Agnieszka D′Antonio-Chronowska Florence Coulet Katrina M. Olson Christopher DeBoever Frauke Drees Angelo Arias Hakan Alakus Andrea L. Richardson Richard B. Schwab Emma K. Farley Shamil R. Sunyaev Kelly A Frazer |
| author_sort |
Matteo D′Antonio |
| title |
Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer |
| title_short |
Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer |
| title_full |
Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer |
| title_fullStr |
Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer |
| title_full_unstemmed |
Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer |
| title_sort |
identifying dnase i hypersensitive sites as driver distal regulatory elements in breast cancer |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-09-01 |
| description |
Cancer driver mutations can occur within noncoding genomic sequences. Here, the authors develop a statistical approach to identify candidate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally demonstrate they are regulatory elements of known cancer genes. |
| url |
https://doi.org/10.1038/s41467-017-00100-x |
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