Pathogenicity of Clinical OXA-48 Isolates and Impact of the OXA-48 IncL Plasmid on Virulence and Bacterial Fitness

Pathogenicity of Clinical OXA-48 Isolates and Impact of the OXA-48 IncL Plasmid on Virulence and Bacterial Fitness

OXA-48 is the most common carbapenemase in Enterobacterales in Germany and one of the most frequent carbapenemases worldwide. Several reports have associated blaOXA–48 with a virulent host phenotype. To challenge this hypothesis, 35 OXA-48-producing clinical isolates of Escherichia coli (n = 15) and...

Full description

Bibliographic Details
Main Authors: Axel Hamprecht, Julian Sommer, Matthias Willmann, Christina Brender, Yvonne Stelzer, Felix F. Krause, Tsvetan Tsvetkov, Florian Wild, Sara Riedel-Christ, Julia Kutschenreuter, Can Imirzalioglu, Aitor Gonzaga, Ulrich Nübel, Stephan Göttig
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Microbiology
Subjects:
OXA-48
carbapenemases
IncL
β-lactamases
virulence
fitness
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02509/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.02509/full

Similar Items