IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and regulation are reduced. Authors also note an over...

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Main Authors: Bruce A. Rosa, Mushtaq Ahmed, Dhiraj K. Singh, José Alberto Choreño-Parra, Journey Cole, Luis Armando Jiménez-Álvarez, Tatiana Sofía Rodríguez-Reyna, Bindu Singh, Olga Gonzalez, Ricardo Carrion, Larry S. Schlesinger, John Martin, Joaquín Zúñiga, Makedonka Mitreva, Deepak Kaushal, Shabaana A. Khader
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01829-4
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spelling doaj-fee1d848484c4499aa50fa45ecb7d32f2021-03-11T12:04:33ZengNature Publishing GroupCommunications Biology2399-36422021-03-014111410.1038/s42003-021-01829-4IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infectionBruce A. Rosa0Mushtaq Ahmed1Dhiraj K. Singh2José Alberto Choreño-Parra3Journey Cole4Luis Armando Jiménez-Álvarez5Tatiana Sofía Rodríguez-Reyna6Bindu Singh7Olga Gonzalez8Ricardo Carrion9Larry S. Schlesinger10John Martin11Joaquín Zúñiga12Makedonka Mitreva13Deepak Kaushal14Shabaana A. Khader15Department of Medicine, Washington University in St. LouisDepartment of Molecular Microbiology, Washington University in St. LouisSouthwest National Primate Research Center, Texas Biomedical Research InstituteLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío VillegasSouthwest National Primate Research Center, Texas Biomedical Research InstituteLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío VillegasDepartment of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránSouthwest National Primate Research Center, Texas Biomedical Research InstituteSouthwest National Primate Research Center, Texas Biomedical Research InstituteSouthwest National Primate Research Center, Texas Biomedical Research InstituteSouthwest National Primate Research Center, Texas Biomedical Research InstituteDepartment of Medicine, Washington University in St. LouisLaboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío VillegasDepartment of Medicine, Washington University in St. LouisSouthwest National Primate Research Center, Texas Biomedical Research InstituteDepartment of Molecular Microbiology, Washington University in St. LouisRosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and regulation are reduced. Authors also note an overlap of genes associated with SARS-CoV-2 infection and tuberculosis, altogether providing new insights into the immunopathogenesis of COVID-19 disease.https://doi.org/10.1038/s42003-021-01829-4
collection DOAJ
language English
format Article
sources DOAJ
author Bruce A. Rosa
Mushtaq Ahmed
Dhiraj K. Singh
José Alberto Choreño-Parra
Journey Cole
Luis Armando Jiménez-Álvarez
Tatiana Sofía Rodríguez-Reyna
Bindu Singh
Olga Gonzalez
Ricardo Carrion
Larry S. Schlesinger
John Martin
Joaquín Zúñiga
Makedonka Mitreva
Deepak Kaushal
Shabaana A. Khader
spellingShingle Bruce A. Rosa
Mushtaq Ahmed
Dhiraj K. Singh
José Alberto Choreño-Parra
Journey Cole
Luis Armando Jiménez-Álvarez
Tatiana Sofía Rodríguez-Reyna
Bindu Singh
Olga Gonzalez
Ricardo Carrion
Larry S. Schlesinger
John Martin
Joaquín Zúñiga
Makedonka Mitreva
Deepak Kaushal
Shabaana A. Khader
IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
Communications Biology
author_facet Bruce A. Rosa
Mushtaq Ahmed
Dhiraj K. Singh
José Alberto Choreño-Parra
Journey Cole
Luis Armando Jiménez-Álvarez
Tatiana Sofía Rodríguez-Reyna
Bindu Singh
Olga Gonzalez
Ricardo Carrion
Larry S. Schlesinger
John Martin
Joaquín Zúñiga
Makedonka Mitreva
Deepak Kaushal
Shabaana A. Khader
author_sort Bruce A. Rosa
title IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_short IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_full IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_fullStr IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_full_unstemmed IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection
title_sort ifn signaling and neutrophil degranulation transcriptional signatures are induced during sars-cov-2 infection
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-03-01
description Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and regulation are reduced. Authors also note an overlap of genes associated with SARS-CoV-2 infection and tuberculosis, altogether providing new insights into the immunopathogenesis of COVID-19 disease.
url https://doi.org/10.1038/s42003-021-01829-4
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