Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome?
Although the treatment of multiple-injured patients has been improved during the last decades, sepsis and multiple organ failure (MOF) still remain the major cause of death. Following trauma, profound alterations of a large number of physiological systems can be observed that may potentially contrib...
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doaj-fee2f9dbf84a45d8b82ddcdb2b5cd4182020-11-25T03:07:20ZengMDPI AGJournal of Clinical Medicine2077-03832020-07-0192287228710.3390/jcm9072287Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome?Philipp Kobbe0Felix M. Bläsius1Philipp Lichte2Reiner Oberbeck3Frank Hildebrand4Deparment of Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, D-52074 Aachen, GermanyDeparment of Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, D-52074 Aachen, GermanyDeparment of Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, D-52074 Aachen, GermanyDeparment of Trauma and Hand Surgery, Wald-Klinikum, 07548 Gera, GermanyDeparment of Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, D-52074 Aachen, GermanyAlthough the treatment of multiple-injured patients has been improved during the last decades, sepsis and multiple organ failure (MOF) still remain the major cause of death. Following trauma, profound alterations of a large number of physiological systems can be observed that may potentially contribute to the development of sepsis and MOF. This includes alterations of the neuroendocrine and the immune system. A large number of studies focused on posttraumatic changes of the immune system, but the cause of posttraumatic immune disturbance remains to be established. However, an increasing number of data indicate that the bidirectional interaction between the neuroendocrine and the immune system may be an important mechanism involved in the development of sepsis and MOF. The aim of this article is to highlight the current knowledge of the neuroendocrine modulation of the immune system during trauma and sepsis.https://www.mdpi.com/2077-0383/9/7/2287traumasepsisDHEAsteroidscatecholamine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Philipp Kobbe Felix M. Bläsius Philipp Lichte Reiner Oberbeck Frank Hildebrand |
spellingShingle |
Philipp Kobbe Felix M. Bläsius Philipp Lichte Reiner Oberbeck Frank Hildebrand Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome? Journal of Clinical Medicine trauma sepsis DHEA steroids catecholamine |
author_facet |
Philipp Kobbe Felix M. Bläsius Philipp Lichte Reiner Oberbeck Frank Hildebrand |
author_sort |
Philipp Kobbe |
title |
Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome? |
title_short |
Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome? |
title_full |
Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome? |
title_fullStr |
Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome? |
title_full_unstemmed |
Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome? |
title_sort |
neuroendocrine modulation of the immune response after trauma and sepsis: does it influence outcome? |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-07-01 |
description |
Although the treatment of multiple-injured patients has been improved during the last decades, sepsis and multiple organ failure (MOF) still remain the major cause of death. Following trauma, profound alterations of a large number of physiological systems can be observed that may potentially contribute to the development of sepsis and MOF. This includes alterations of the neuroendocrine and the immune system. A large number of studies focused on posttraumatic changes of the immune system, but the cause of posttraumatic immune disturbance remains to be established. However, an increasing number of data indicate that the bidirectional interaction between the neuroendocrine and the immune system may be an important mechanism involved in the development of sepsis and MOF. The aim of this article is to highlight the current knowledge of the neuroendocrine modulation of the immune system during trauma and sepsis. |
topic |
trauma sepsis DHEA steroids catecholamine |
url |
https://www.mdpi.com/2077-0383/9/7/2287 |
work_keys_str_mv |
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