Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period
Introduction: We evaluated the association between carotid compliance, a measure of arterial stiffness, to parahippocampal volume (PHV) and hippocampal volume (HV) over 20 years later in the Atherosclerosis Risk in the Community study. Methods: We included participants with common carotid compliance...
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doaj-feefb61ed55b48aa93122c41f520c4ee2021-10-07T13:44:28ZengKarger PublishersDementia and Geriatric Cognitive Disorders Extra1664-54642021-09-0111322723410.1159/000518234518234Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year PeriodHediyeh Baradaran0Alen Delic1J. Scott McNally2Matthew Alexander3Jennifer J. Majersik4Dennis L. Parker5Adam de Havenon6Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USADepartment of Neurology, University of Utah, Salt Lake City, UT, USADepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USADepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USADepartment of Neurology, University of Utah, Salt Lake City, UT, USADepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USADepartment of Neurology, University of Utah, Salt Lake City, UT, USAIntroduction: We evaluated the association between carotid compliance, a measure of arterial stiffness, to parahippocampal volume (PHV) and hippocampal volume (HV) over 20 years later in the Atherosclerosis Risk in the Community study. Methods: We included participants with common carotid compliance measurements at visit 1 (1987–1989) and volumetric brain MRI at visit 5 (2011–2013). The primary outcomes are pooled bilateral PHV and HV. We performed linear regression models adjusting for age, sex, vascular risk factors, and total brain volume. Results: Of the 614 participants, higher compliance was correlated with higher PHV (R = 0.218[0.144–0.291], p < 0.001) and HV (R = 0.181 [0.105–0.255, p < 0.001]). The association was linear and significant after adjusting for confounders. At follow-up MRI, 30 patients with dementia had lower PHV and HV than patients without dementia (p < 0.001 and p < 0.001, respectively). Conclusion: Carotid compliance is associated with higher PHV and HV when measured 20 years later, further supporting the link between arterial stiffness and cognitive decline.https://www.karger.com/Article/FullText/518234brain imagingcerebrovascular diseasesvascular causes of cognitive impairment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hediyeh Baradaran Alen Delic J. Scott McNally Matthew Alexander Jennifer J. Majersik Dennis L. Parker Adam de Havenon |
spellingShingle |
Hediyeh Baradaran Alen Delic J. Scott McNally Matthew Alexander Jennifer J. Majersik Dennis L. Parker Adam de Havenon Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period Dementia and Geriatric Cognitive Disorders Extra brain imaging cerebrovascular diseases vascular causes of cognitive impairment |
author_facet |
Hediyeh Baradaran Alen Delic J. Scott McNally Matthew Alexander Jennifer J. Majersik Dennis L. Parker Adam de Havenon |
author_sort |
Hediyeh Baradaran |
title |
Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period |
title_short |
Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period |
title_full |
Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period |
title_fullStr |
Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period |
title_full_unstemmed |
Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period |
title_sort |
carotid compliance and parahippocampal and hippocampal volume over a 20-year period |
publisher |
Karger Publishers |
series |
Dementia and Geriatric Cognitive Disorders Extra |
issn |
1664-5464 |
publishDate |
2021-09-01 |
description |
Introduction: We evaluated the association between carotid compliance, a measure of arterial stiffness, to parahippocampal volume (PHV) and hippocampal volume (HV) over 20 years later in the Atherosclerosis Risk in the Community study. Methods: We included participants with common carotid compliance measurements at visit 1 (1987–1989) and volumetric brain MRI at visit 5 (2011–2013). The primary outcomes are pooled bilateral PHV and HV. We performed linear regression models adjusting for age, sex, vascular risk factors, and total brain volume. Results: Of the 614 participants, higher compliance was correlated with higher PHV (R = 0.218[0.144–0.291], p < 0.001) and HV (R = 0.181 [0.105–0.255, p < 0.001]). The association was linear and significant after adjusting for confounders. At follow-up MRI, 30 patients with dementia had lower PHV and HV than patients without dementia (p < 0.001 and p < 0.001, respectively). Conclusion: Carotid compliance is associated with higher PHV and HV when measured 20 years later, further supporting the link between arterial stiffness and cognitive decline. |
topic |
brain imaging cerebrovascular diseases vascular causes of cognitive impairment |
url |
https://www.karger.com/Article/FullText/518234 |
work_keys_str_mv |
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