Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic Neuralgia
In acute and ongoing pain, the spontaneous oscillatory activity of electroencephalogram (EEG) has been characterized by suppression of alpha band oscillations and enhancement of gamma band oscillations. In pathological chronic pain which is more severe and common in clinic practice, it is of great i...
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doaj-fef3f37e044b4ac2ac6511d08f7471a02020-11-24T21:21:44ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2018-10-011210.3389/fnins.2018.00750378140Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic NeuralgiaRui Zhou0Jing Wang1Wenjing Qi2Feng-Yu Liu3Ming Yi4Huailian Guo5You Wan6You Wan7Neuroscience Research Institute, Peking University, Beijing, ChinaDepartment of Neurobiology, School of Basic Medical Sciences, Beijing Institute For Brain Disorders, Capital Medical University, Beijing, ChinaDepartment of Rehabilitation Medicine, Peking University Third Hospital, Beijing, ChinaNeuroscience Research Institute, Peking University, Beijing, ChinaNeuroscience Research Institute, Peking University, Beijing, ChinaDepartment of Neurology, Peking University People’s Hospital, Beijing, ChinaNeuroscience Research Institute, Peking University, Beijing, ChinaKey Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, ChinaIn acute and ongoing pain, the spontaneous oscillatory activity of electroencephalogram (EEG) has been characterized by suppression of alpha band oscillations and enhancement of gamma band oscillations. In pathological chronic pain which is more severe and common in clinic practice, it is of great interest to investigate the oscillatory activity especially at the broad gamma frequency bands. Our present study explored the resting state oscillatory activities of EEG in patients with post-herpetic neuralgia (PHN) over 3 months which is a typical neuropathic pain model in clinical researches. It was found that the PHN patients showed anxiety and depression revealed by Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) examinations. Power spectrum analysis revealed that the power at gamma frequency band (from 40 to 70 Hz) of EEG was significantly higher in the PHN patients, and positively correlated with pain intensity, anxiety, and depression indexes. Further, increased gamma activity derived from the prefrontal cortex and the cerebellum were revealed by cluster-based sensor level and the beamforming source level analyses. These results suggest the enhanced gamma oscillatory activity in the prefrontal cortex and cerebellum is a characteristic marker in chronic neuropathic pain patients.https://www.frontiersin.org/article/10.3389/fnins.2018.00750/fullchronic painpost-herpetic neuralgiaelectroencephalogramgamma rhythmpower spectrum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rui Zhou Jing Wang Wenjing Qi Feng-Yu Liu Ming Yi Huailian Guo You Wan You Wan |
spellingShingle |
Rui Zhou Jing Wang Wenjing Qi Feng-Yu Liu Ming Yi Huailian Guo You Wan You Wan Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic Neuralgia Frontiers in Neuroscience chronic pain post-herpetic neuralgia electroencephalogram gamma rhythm power spectrum |
author_facet |
Rui Zhou Jing Wang Wenjing Qi Feng-Yu Liu Ming Yi Huailian Guo You Wan You Wan |
author_sort |
Rui Zhou |
title |
Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic Neuralgia |
title_short |
Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic Neuralgia |
title_full |
Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic Neuralgia |
title_fullStr |
Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic Neuralgia |
title_full_unstemmed |
Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic Neuralgia |
title_sort |
elevated resting state gamma oscillatory activities in electroencephalogram of patients with post-herpetic neuralgia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2018-10-01 |
description |
In acute and ongoing pain, the spontaneous oscillatory activity of electroencephalogram (EEG) has been characterized by suppression of alpha band oscillations and enhancement of gamma band oscillations. In pathological chronic pain which is more severe and common in clinic practice, it is of great interest to investigate the oscillatory activity especially at the broad gamma frequency bands. Our present study explored the resting state oscillatory activities of EEG in patients with post-herpetic neuralgia (PHN) over 3 months which is a typical neuropathic pain model in clinical researches. It was found that the PHN patients showed anxiety and depression revealed by Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) examinations. Power spectrum analysis revealed that the power at gamma frequency band (from 40 to 70 Hz) of EEG was significantly higher in the PHN patients, and positively correlated with pain intensity, anxiety, and depression indexes. Further, increased gamma activity derived from the prefrontal cortex and the cerebellum were revealed by cluster-based sensor level and the beamforming source level analyses. These results suggest the enhanced gamma oscillatory activity in the prefrontal cortex and cerebellum is a characteristic marker in chronic neuropathic pain patients. |
topic |
chronic pain post-herpetic neuralgia electroencephalogram gamma rhythm power spectrum |
url |
https://www.frontiersin.org/article/10.3389/fnins.2018.00750/full |
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