Effect of various cells on the activation of hepatic stellate cells in liver microenvironment
Liver fibrosis is a dynamic pathological process characterized by excessive deposition of extracellular matrix (ECM) or hyperplasia of scar tissue. The activation of hepatic stellate cells (HSCs) is generally considered the central link in the formation of liver fibrosis. HSC activation is regulated...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Hepatology
2019-02-01
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| Series: | Linchuang Gandanbing Zazhi |
| Online Access: | http://www.lcgdbzz.org/qk_content.asp?id=9621 |
| Summary: | Liver fibrosis is a dynamic pathological process characterized by excessive deposition of extracellular matrix (ECM) or hyperplasia of scar tissue. The activation of hepatic stellate cells (HSCs) is generally considered the central link in the formation of liver fibrosis. HSC activation is regulated by various factors in liver microenvironment, including physical and chemical stimulations and intercellular interactions. Intrinsic cells and immune cells in the liver and HSCs together establish a complex regulatory system to regulate HSC activation and regression. This article introduces the regulatory effect of the cells in liver microenvironment on HSC activation, in order to expand thinking for the research on new diagnosis and treatment methods for liver fibrosis. |
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| ISSN: | 1001-5256 1001-5256 |