Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice

Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice

In the present study, we investigated whether the peripherally acting µ-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain. Subcutaneous (s.c.) injection of loperamide (1 and 3 mg/kg) inhibited allodynia. Local (intraplantar) injection...

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Bibliographic Details
Main Authors:	Atsushi Sasaki, Yasutaka Nakashima, Ichiro Takasaki, Tsugunobu Andoh, Kimiyasu Shiraki, Yasushi Kuraishi
Format:	Article
Language:	English
Published:	Elsevier 2007-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S134786131934246X

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