| Summary: | <p><strong>Objective</strong> To investigate the clinical characteristics of Takotsubo cardiomyopathy (TTC) following intracranial aneurysmal subarachnoid hemorrhage (SAH). <strong>Methods</strong> Review all patients with intracranial aneurysmal SAH from January 2013 to January 2015 in our hospital, and finally a total of 14 patients who complicated TTC were selected. Their clinical data, creatine kinase (CK), creatine kinase isoenzyme MB (CK-MB), N-terminal pro-B-type natriuretic peptide (NT-proBNP), ECG and echocardiographic findings were analyzed. <strong>Results </strong> For 14 patients of TTC following aneurysmal SAH, the value of CK was (591.93 ± 248.78) IU/L in the first 24 h on admission, and significantly decreased to (137.79 ± 29.93) IU/L 2 weeks later (<em>t</em> = 7.090, <em>P</em> = 0.000); the value of CK-MB was (27.07 ± 7.66) IU/L in the first 24 h (3 cases were at normal levels), and significantly decreased to (14.36 ± 5.58) IU/L 2 weeks later (<em>t</em> = 4.897, <em>P</em> = 0.000); the value of NT-proBNP was (8685.36 ± 3963.44) IU/L in the first 24 h, and significantly decreased to (577.14 ± 203.37) IU/L 2 weeks later (<em>t</em> = 7.778,<em> P</em> = 0.000). ECG on admission mainly showed ST segment alternation, T wave inversion and QT interval prolongation. Echocardiograghic findings showed segmental left ventricular wall motion abnormalities. The average left ventricular ejection fraction (LVEF) was (36.07 ± 6.15)%, and increased to (56.43 ± 3.18)% 2 weeks later (<em>t</em> = 13.381, <em>P</em> = 0.000). The results of ECG and echocardiographic findings were normal after one month. <strong>Conclusions </strong> Intracranial aneurysmal SAH can lead to Takotsubo cardiomyopathy, the incidence of which is 4.58% approximately, and the prognosis is good. Echocardiographic findings are significantly important for early screening of Takotsubo cardiomyopathy, and coronary angiography (CAG) can be used to make a clear diagnosis in acute phase.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2016.06.010</p>
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