Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer

Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer

Abstract Background Gastric cancer (GC) is a common cancer in Asia and currently lacks a targeted therapy approach. Mesothelin (MSLN) has been reported to be expressed in GC tissue and could be targeted by chimeric antigen receptor (CAR) T cells. Mesothelin targeting CAR-T has been reported in mesot...

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Bibliographic Details
Main Authors: Jiang Lv, Ruocong Zhao, Di Wu, Diwei Zheng, Zhiping Wu, Jingxuan Shi, Xinru Wei, Qiting Wu, Youguo Long, Simiao Lin, Suna Wang, Zhi Wang, Yang Li, Yantao Chen, Qing He, Suimin Chen, Huihui Yao, Zixia Liu, Zhaoyang Tang, Yao Yao, Duanqing Pei, Pentao Liu, Xuchao Zhang, Zhenfeng Zhang, Shuzhong Cui, Ren Chen, Peng Li
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Hematology & Oncology
Subjects:
Gastric cancer
Mesothelin
Chimeric antigen receptor T cells
Immunotherapy
Immunodeficient mice
Online Access:http://link.springer.com/article/10.1186/s13045-019-0704-y

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