Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral <em>Echinomuricea</em> sp.

• Main Authors: Ching-Hsiao Cheng, Hsu-Ming Chung, Tsong-Long Hwang, Mei-Chin Lu, Zhi-Hong Wen, Yueh-Hsiung Kuo, Wei-Hsien Wang, Ping-Jyun Sung
• Format: Article
• Language: English
• Published: MDPI AG 2012-08-01
• Series: Molecules
• Subjects: <em>Echinomuricea</em> clerodane diterpene; echinoclerodane; cytotoxicity; superoxide anion; elastase
• Online Access: http://www.mdpi.com/1420-3049/17/8/9443

A new clerodane-type diterpenoid, echinoclerodane A (<strong>1</strong>), was isolated from a Formosan gorgonian coral <em>Echinomuricea</em> sp. The structure of <strong>1</strong> was elucidated by spectroscopic methods. Echinoclerodane A (<strong>1</strong>) is the first clerodane-type compound obtained from the marine organisms belonging to the phylum Cnidaria. Echinoclerodane A (<strong>1</strong>) exhibited moderate cytotoxicity toward MOLT-4, HL-60, DLD-1 and LoVo tumor cells and inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.