Effect of vitamin D intervention on the RAAS system activity and cardiovascular remodeling in spontaneously hypertensive rats

• Main Authors: Hui Li1, Can Ling2
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Essential hypertension Vitamin d Renin-angiotensin-aldosterone Myocardial remodeling
• Online Access: http://www.hnykdxxb.com/PDF/201707/3.pdf

Objective: To study the effect of vitamin D intervention on the renin-angiotensin-aldosterone system (RAAS) system activity and cardiovascular remodeling in spontaneously hypertensive rats. Methods: Healthy SD rats were selected as the control group, spontaneously hypertensive rats were randomly divided into hypertension group and VitD group, control group and hypertension group received intraperitoneal injection of propylene glycol, and VitD group received intraperitoneal injection of vitamin D and propylene glycol solution. 6 weeks, 12 weeks and 18 weeks after intervention, the rats were put to death, serum was collected to determine the levels of RAAS system molecules, and the myocardial tissue was collected to determine the levels of cardiovascular remodeling-related molecules. Results: 6 weeks, 12 weeks and 18 weeks after intervention, serum serum renin (PRA), angiotensin II (AngII) and aldosterone (ALD) levels as well as myocardial tissue Col-I, Col-III, TGF-β1, α-actin and Myom-1 levels of hypertension group gradually increased and were significantly higher than those of control group (P<0.05); serum PRA, AngII and ALD levels as well as myocardial tissue Col-I, Col-III, TGF-β1, α-actin and Myom-1 levels of VitD group gradually decreased and were significantly lower than those of hypertension group (P<0.05). Conclusion: Vitamin D intervention for spontaneously hypertensive rats can reduce the RAAS system activity and improve the cardiovascular remodeling.