Self-digitization chip for single-cell genotyping of cancer-related mutations.
Cancer is a heterogeneous disease, and patient-level genetic assessments can guide therapy choice and impact prognosis. However, little is known about the impact of genetic variability within a tumor, intratumoral heterogeneity (ITH), on disease progression or outcome. Current approaches using bulk...
Main Authors: | Alison M Thompson, Jordan L Smith, Luke D Monroe, Jason E Kreutz, Thomas Schneider, Bryant S Fujimoto, Daniel T Chiu, Jerald P Radich, Amy L Paguirigan |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5931502?pdf=render |
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